MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Body mass index (BMI) | 0.0243 | 0.00486 | 5.71e-07 | Wald ratio | 1 | cis | NA |
| Weight | 0.0194 | 0.00429 | 5.89e-06 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | 0.15 | 0.0487 | 0.00203 | Wald ratio | 1 | cis | NA |
| Low grade serous ovarian cancer | -0.273 | 0.0991 | 0.00584 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0108 | 0.00399 | 0.00671 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0344 | 0.0127 | 0.00682 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Wrist | 0.0822 | 0.032 | 0.0101 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd | 0.176 | 0.0702 | 0.0123 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pernicious anaemia | 0.18 | 0.0752 | 0.0167 | Wald ratio | 1 | cis | NA |
| Cough on most days | -0.0618 | 0.0264 | 0.0191 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | -0.0751 | 0.0339 | 0.0268 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | 0.0159 | 0.00718 | 0.0271 | Wald ratio | 1 | cis | NA |
| …and 71 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
48 association rows across 28 traits (43 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating GDF15 levels | 1e-851 | rs1054221 | 3 | GCST90859943 | no MR -> candidate analysis |
| Growth differentiation factor-15 levels | 3e-250 | rs1227734 | 5 | GCST90011998 | no MR -> candidate analysis |
| Growth/differentiation factor 15 levels | 3e-175 | rs75347775 | 7 | GCST90247708 | no MR -> candidate analysis |
| Serum levels of protein GDF15 | 1e-102 | rs1058587 | 2 | GCST90088672 | no MR -> candidate analysis |
| GDF15 protein levels | 2e-54 | rs113700483 | 5 | GCST90469321 | no MR -> candidate analysis |
| Severity of nausea and vomiting of pregnancy | 2e-41 | rs16982345 | 1 | GCST005929 | no MR -> candidate analysis |
| Growth/differentiation factor 15 levels (GDF15.4374.45.2) | 1e-34 | rs1227734 | 1 | GCST90241351 | no MR -> candidate analysis |
| Cerebrospinal fluid protein GDF15 levels | 3e-27 | rs62122429 | 1 | GCST90944768 | no MR -> candidate analysis |
| Growth differentiation factor-15 levels (conditioned on rs88 | 1e-22 | rs1059519 | 2 | GCST005712 | no MR -> candidate analysis |
| LRRC25 protein levels | 7e-22 | rs62122428 | 1 | GCST90469801 | no MR -> candidate analysis |
| Hyperemesis gravidarum | 2e-19 | rs16982345 | 1 | GCST005930 | no MR -> candidate analysis |
| mean corpuscular volume (MCV, minimum, inv-norm transformed) | 4e-15 | rs8110358 | 1 | GCST90479677 | no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
Top diseases by Open Targets association (of 1595 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hyperemesis gravidarum | 0.703 | — | established (curated) | no MR -> candidate analysis |
| coffee consumption | 0.678 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.251 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.079 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.037 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.048 | — | common-variant locus | no MR -> candidate analysis |
Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Growth/differentiation factor 15) |
| gnomAD constraint | pLI=0.00013, LOEUF=1.9 — LoF-tolerant |
| GWAS Catalog | 189 unique SNPs / 505 rows |
| ClinVar | 71 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1595 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘GDF15’ and resolved to ‘Growth/differentiation factor 15’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 71 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 48 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q99988 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000130513/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3120039/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/GDF15 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GDF15 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GDF15%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GDF15 — GWAS Catalog search API (live; release not exposed)