MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: high cholesterol | -0.0272 | 0.00962 | 0.0047 | Wald ratio | 1 | cis | NA |
| Squamous cell lung cancer | 0.0991 | 0.0361 | 0.00602 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages | 0.116 | 0.0429 | 0.00686 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0123 | 0.00512 | 0.0164 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K44 Diaphragmatic hernia | -0.0708 | 0.0298 | 0.0173 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | -0.0627 | 0.0265 | 0.0182 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: migraine | -0.0458 | 0.0209 | 0.0286 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: ankylosing spondylitis | -0.161 | 0.0774 | 0.0371 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | 0.0435 | 0.0213 | 0.0411 | Wald ratio | 1 | cis | NA |
| Subjective well being | 0.00965 | 0.00483 | 0.0455 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | -0.0089 | 0.00448 | 0.047 | Wald ratio | 1 | cis | NA |
| Schizophrenia | 0.03 | 0.0152 | 0.0482 | Wald ratio | 1 | cis | NA |
| …and 108 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
20 association rows across 16 traits (14 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| D-glucuronyl C5-epimerase levels | 1e-693 | rs35810867 | 3 | GCST90247272 | no MR -> candidate analysis |
| D-glucuronyl C5-epimerase levels (GLCE.7808.5.3) | 8e-245 | rs11854180 | 1 | GCST90240871 | no MR -> candidate analysis |
| Blood protein levels | 2e-229 | rs3865014 | 1 | GCST006585 | no MR -> candidate analysis |
| D-glucuronyl C5-epimerase level in Chronic kidney disease wi | 8e-85 | rs3865014 | 1 | GCST90238640 | no MR -> candidate analysis |
| systolic blood pressure (SBP, maximum, inv-normal transforme | 6e-12 | rs11629932 | 1 | GCST90480705 | no MR -> candidate analysis |
| Medication use for hypertension (number of purchases) | 1e-11 | rs199641012 | 1 | GCST90250905 | no MR -> candidate analysis |
| ER membrane protein complex subunit 1 protein levels (SomaSc | 2e-11 | rs3865014 | 1 | GCST90437733 | no MR -> candidate analysis |
| Smoking initiation | 2e-9 | rs2899748 | 1 | GCST90243985 | no MR -> candidate analysis |
| Mean corpuscular hemoglobin | 2e-9 | rs148377198 | 3 | GCST007068 | no MR -> candidate analysis |
| Peak expiratory flow | 4e-9 | rs71147591 | 1 | GCST90270085 | no MR -> candidate analysis |
| Empathy quotient | 7e-7 | rs201219357 | 1 | GCST005751 | no MR -> candidate analysis |
| R-6-hydroxywarfarin levels | 1e-6 | rs149533198 | 1 | GCST90129566 | no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
Top diseases by Open Targets association (of 2390 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.437 | — | common-variant locus | no MR -> candidate analysis |
| inherited hemoglobinopathy | 0.397 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.36 | — | common-variant locus | no MR -> candidate analysis |
| inherited retinal dystrophy | 0.353 | — | common-variant locus | no MR -> candidate analysis |
| septic shock | 0.158 | — | common-variant locus | no MR -> candidate analysis |
Of the 5 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.48, LOEUF=0.582 — LoF-tolerant |
| GWAS Catalog | 33 unique SNPs / 66 rows |
| ClinVar | 76 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 2390 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘GLCE’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 76 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 20 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O94923 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000138604/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/GLCE — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GLCE — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GLCE%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GLCE — GWAS Catalog search API (live; release not exposed)