MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Body mass index (BMI) | 0.0584 | 0.0147 | 7.60e-05 | Wald ratio | 1 | cis | NA |
| Weight | 0.0471 | 0.013 | 3.00e-04 | Wald ratio | 1 | cis | NA |
| Sleep duration | 0.0347 | 0.0115 | 0.0026 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K43 Ventral hernia | 0.432 | 0.148 | 0.00345 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: prostate cancer | 0.357 | 0.123 | 0.00376 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.186 | 0.069 | 0.00693 | Wald ratio | 1 | cis | NA |
| Cigarettes smoked per day | -1.27 | 0.495 | 0.0105 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | 0.194 | 0.0787 | 0.0137 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Cataract | 0.159 | 0.0692 | 0.0213 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | 0.352 | 0.167 | 0.0349 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.178 | 0.087 | 0.0412 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K20 Oesophagitis | 0.236 | 0.12 | 0.0491 | Wald ratio | 1 | cis | NA |
| …and 86 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
19 association rows across 15 traits (15 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| GLO1/GLOD4 protein level ratio | 1e-948 | rs4746 | 1 | GCST90314934 | no MR -> candidate analysis |
| Circulating GLO1 levels | 3e-718 | rs4714175 | 2 | GCST90859780 | no MR -> candidate analysis |
| GLO1/S100A4 protein level ratio | 5e-647 | rs4746 | 1 | GCST90314935 | no MR -> candidate analysis |
| Cerebrospinal fluid protein GLO1 levels | 2e-95 | rs4746 | 1 | GCST90943424 | no MR -> candidate analysis |
| Lactoylglutathione lyase levels | 5e-51 | rs4746 | 2 | GCST90179310 | no MR -> candidate analysis |
| Serum levels of protein GLO1 | 1e-15 | rs13200763 | 1 | GCST90090884 | no MR -> candidate analysis |
| MDGA1 protein levels | 8e-14 | rs114306573 | 1 | GCST90469875 | no MR -> candidate analysis |
| GLO1 protein levels | 2e-12 | rs4746 | 1 | GCST90277607 | no MR -> candidate analysis |
| Insomnia | 1e-11 | rs7747615 | 3 | GCST90131901 | no MR -> candidate analysis |
| Blood protein levels | 7e-11 | rs12209477 | 1 | GCST006585 | no MR -> candidate analysis |
| LGUL protein level (protein group normalized intensity) | 2e-9 | rs4714175 | 1 | GCST90570960 | no MR -> candidate analysis |
| Gut microbiome abundance (class Clostridium sensu stricto sp | 1e-7 | rs1616723 | 1 | GCST90569614 | no MR -> candidate analysis |
| …and 3 more traits (see JSON) |
Top diseases by Open Targets association (of 384 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| migraine disorder | 0.423 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.128 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.126 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.111 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.111 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.11 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes nephropathy | 0.109 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Lactoylglutathione lyase) |
| gnomAD constraint | pLI=8.4e-11, LOEUF=1.48 — LoF-tolerant |
| GWAS Catalog | 34 unique SNPs / 68 rows |
| ClinVar | 25 records; 6 pathogenic in sample of 25 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 384 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘GLO1’ and resolved to ‘Lactoylglutathione lyase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 25 record(s) retrieved, NOT over all 25 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 15 of 15 traits by best p-value, aggregated from 19 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q04760 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000124767/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2424/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/GLO1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GLO1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GLO1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GLO1 — GWAS Catalog search API (live; release not exposed)