CausalSentinel

Protein Dossier — GLTD2

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Diagnoses - main ICD10: G47 Sleep disorders	0.262	0.0963	0.00654	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: bladder problem (not cancer)	0.243	0.0987	0.0137	Wald ratio	1	cis	NA
Pallidum volume	-20.7	8.49	0.0148	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: sleep apnoea	0.293	0.13	0.0245	Wald ratio	1	cis	NA
Diagnoses - main ICD10: I30 Acute pericarditis	0.678	0.306	0.0268	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: osteoarthritis	-0.0718	0.0341	0.0355	Wald ratio	1	cis	NA
Sleep duration	-0.0147	0.0074	0.0473	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: high cholesterol	0.0481	0.0245	0.0495	Wald ratio	1	cis	NA
Diagnoses - main ICD10: M54 Dorsalgia	-0.158	0.0871	0.0691	Wald ratio	1	cis	NA
Invasive mucinous ovarian cancer	0.27	0.158	0.088	Wald ratio	1	cis	NA
Diagnoses - main ICD10: K29 Gastritis and duodenitis	-0.115	0.0692	0.098	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: hiatus hernia	-0.116	0.0703	0.0984	Wald ratio	1	cis	NA
…and 65 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

No GWAS Catalog associations mapped to this gene.

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

No genetically-associated diseases retrieved from Open Targets.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	not available
GWAS Catalog	no mapped SNPs
ClinVar	no records
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• uniprot — No reviewed human UniProt entry for ‘GLTD2’.
• phenome — Could not resolve target ‘GLTD2’.
• chembl — No ChEMBL target for ‘GLTD2’.
• gnomad — No gnomAD constraint data.
• gwas — No GWAS Catalog SNPs mapped to this gene.
• clinvar — No ClinVar records.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — No GWAS Catalog associations mapped to this gene.

Sources

• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0

Provenance

• Generated: 2026-08-14T02:50:03 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

This site is open source. Improve this page.