Protein Dossier — GNLY (Granulysin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Birth weight |
0.019 |
0.00556 |
6.29e-04 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.012 |
0.00452 |
0.00788 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K44 Diaphragmatic hernia |
0.0721 |
0.0277 |
0.00921 |
Wald ratio |
1 |
cis |
NA |
| Bipolar disorder |
-0.1 |
0.0388 |
0.00966 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.00913 |
0.0038 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| Vascular or heart problems diagnosed by doctor: Angina |
-0.0512 |
0.0219 |
0.0195 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K40 Inguinal hernia |
0.0499 |
0.0216 |
0.0209 |
Wald ratio |
1 |
cis |
NA |
| Caudate volume |
16.1 |
7.52 |
0.0324 |
Wald ratio |
1 |
cis |
NA |
| IgA nephropathy |
-0.284 |
0.135 |
0.035 |
Wald ratio |
1 |
cis |
NA |
| Age at menopause |
-0.0517 |
0.0259 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone |
-0.0919 |
0.0461 |
0.0461 |
Wald ratio |
1 |
cis |
NA |
| Primary sclerosing cholangitis |
0.0875 |
0.044 |
0.0466 |
Wald ratio |
1 |
cis |
NA |
| …and 86 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3195_50_2 |
Granulysin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
58 association rows across 24 traits (56 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating GNLY levels |
6e-2124 |
rs7603438 |
5 |
GCST90860460 |
no MR -> candidate analysis |
| GNLY/GZMA protein level ratio |
1e-2062 |
rs751163 |
1 |
GCST90314949 |
no MR -> candidate analysis |
| Granulysin levels |
5e-802 |
rs12151621 |
14 |
GCST90247802 |
no MR -> candidate analysis |
| Serum levels of protein GNLY |
7e-260 |
rs12151742 |
4 |
GCST90088260 |
no MR -> candidate analysis |
| Blood protein levels |
5e-214 |
rs7603438 |
3 |
GCST006585 |
no MR -> candidate analysis |
| Granulysin levels (GNLY.3195.50.2) |
7e-189 |
rs12151621 |
2 |
GCST90241322 |
no MR -> candidate analysis |
| Granulysin (analyte X14102.6) levels |
7e-188 |
rs12151742 |
1 |
GCST90422468 |
no MR -> candidate analysis |
| Granulysin (analyte X3195.50) levels |
2e-165 |
rs12151742 |
1 |
GCST90425647 |
no MR -> candidate analysis |
| GNLY protein levels |
8e-158 |
rs192642287 |
12 |
GCST90469372 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein GNLY levels |
2e-87 |
rs7603438 |
1 |
GCST90944771 |
no MR -> candidate analysis |
| Granulysin level in Chronic kidney disease with hypertension |
2e-51 |
rs12151742 |
1 |
GCST90234189 |
no MR -> candidate analysis |
| Granulysin level in Chronic kidney disease with hypertension |
1e-44 |
rs12151742 |
1 |
GCST90237265 |
no MR -> candidate analysis |
| …and 12 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 331 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| cataract |
0.19 |
0.19 |
exploratory rare-variant signal |
MR: beta=-0.0658, p=0.146 (cis) |
| vertebral column disorder |
0.167 |
— |
common-variant locus |
no MR -> candidate analysis |
| brain aneurysm |
0.167 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.087 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 1 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=4.5e-05, LOEUF=1.25 — LoF-tolerant |
| GWAS Catalog |
98 unique SNPs / 187 rows |
| ClinVar |
60 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 331 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘GNLY’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 60 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 24 traits by best p-value, aggregated from 58 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P22749 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000115523/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/GNLY — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GNLY — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GNLY%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GNLY — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:50:16 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none