CausalSentinel

Protein Dossier — GP5 (Platelet glycoprotein V)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Mean platelet volume	-0.023	0.00548	2.63e-05	Inverse variance weighted	2	trans	NA
Mean platelet volume	-0.023	0.00548	2.63e-05	Inverse variance weighted	2	cis	NA
Platelet count	8.65	2.11	4.19e-05	Inverse variance weighted	2	trans	NA
Platelet count	8.65	2.11	4.19e-05	Inverse variance weighted	2	cis	NA
Non-cancer illness code self-reported: osteoarthritis	0.00916	0.00341	0.00716	Inverse variance weighted	2	trans	NA
Non-cancer illness code self-reported: osteoarthritis	0.00916	0.00341	0.00716	Inverse variance weighted	2	cis	NA
Non-cancer illness code self-reported: psoriasis	-0.00353	0.00131	0.00718	Inverse variance weighted	2	trans	NA
Non-cancer illness code self-reported: psoriasis	-0.00353	0.00131	0.00718	Inverse variance weighted	2	cis	NA
Non-cancer illness code self-reported: hypothyroidism or myxoedema	0.0065	0.00262	0.0131	Inverse variance weighted	2	trans	NA
Non-cancer illness code self-reported: hypothyroidism or myxoedema	0.0065	0.00262	0.0131	Inverse variance weighted	2	cis	NA
Sodium in urine	0.0291	0.012	0.0151	Inverse variance weighted	2	trans	NA
Sodium in urine	0.0291	0.012	0.0151	Inverse variance weighted	2	cis	NA
…and 204 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

18 association rows across 11 traits (18 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
GP5 protein levels	4e-68	rs1466733	1	GCST90469383	no MR -> candidate analysis
Platelet count	7e-28	rs544985059	5	GCST90662907	MR: beta=8.65, p=4.19e-05 (trans)
Platelet distribution width	8e-25	rs1466733	2	GCST90002401	no MR -> candidate analysis
Platelet distribution width (UKB data field 30110)	2e-23	rs1466733	1	GCST90468097	no MR -> candidate analysis
Platelet glycoprotein V levels	3e-22	rs1466733	1	GCST90247796	no MR -> candidate analysis
Mean platelet volume	1e-19	rs1466733	3	GCST90002349	MR: beta=-0.023, p=2.63e-05 (trans)
Platelet count (UKB data field 30080)	7e-18	rs1466733	1	GCST90468095	no MR -> candidate analysis
mean platelet volume (MPV, maximum, inv-norm transformed)	9e-18	rs376133816	1	GCST90479707	no MR -> candidate analysis
Mean platelet thrombocyte volume (UKB data field 30100)	1e-16	rs10638925	1	GCST90468087	no MR -> candidate analysis
mean platelet volume (MPV, mean, inv-norm transformed)	6e-16	rs376133816	1	GCST90479708	no MR -> candidate analysis
mean platelet volume (MPV, minimum, inv-norm transformed)	1e-11	rs376133816	1	GCST90479709	no MR -> candidate analysis

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

Top diseases by Open Targets association (of 222 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.

Disease	genetic assoc.	burden (ExWAS)	causal status	MR status
stroke disorder	0.036	—	common-variant locus	no MR -> candidate analysis
decubitus ulcer	0.036	—	common-variant locus	no MR -> candidate analysis
alcohol drinking	0.036	—	common-variant locus	no MR -> candidate analysis

Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=NA, LOEUF=NA — Constraint metrics missing; LoF tolerance cannot be judged.
GWAS Catalog	46 unique SNPs / 92 rows
ClinVar	135 records; 1 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 222 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘GP5’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 135 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 11 of 11 traits by best p-value, aggregated from 18 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/P40197 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000178732/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/GP5 — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/GP5 — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GP5%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/GP5 — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T02:52:15 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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