MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Fractured bone site(s): Ankle | -0.154 | 0.041 | 1.74e-04 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.0122 | 0.00411 | 0.00294 | Wald ratio | 1 | cis | NA |
| Weight | 0.0107 | 0.00363 | 0.00305 | Wald ratio | 1 | cis | NA |
| Ovarian cancer | -0.0614 | 0.0234 | 0.00879 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | 0.0701 | 0.03 | 0.0193 | Wald ratio | 1 | cis | NA |
| Years of schooling | -0.0145 | 0.00645 | 0.0244 | Wald ratio | 1 | cis | NA |
| HbA1C | 0.0134 | 0.00597 | 0.0249 | Wald ratio | 1 | cis | NA |
| Lumbar spine bone mineral density | 0.0343 | 0.0154 | 0.0259 | Wald ratio | 1 | cis | NA |
| Fractured or broken bones in last 5 years | -0.0292 | 0.0132 | 0.0266 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hiatus hernia | 0.055 | 0.0255 | 0.0311 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting | -0.166 | 0.0777 | 0.0329 | Wald ratio | 1 | cis | NA |
| Happiness | 0.0106 | 0.0051 | 0.0367 | Wald ratio | 1 | cis | NA |
| …and 81 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
21 association rows across 11 traits (15 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| GRAM domain-containing protein 1C levels | 3e-338 | rs1872823 | 4 | GCST90247815 | no MR -> candidate analysis |
| Serum levels of protein GRAMD1C | 1e-262 | rs61634901 | 4 | GCST90090335 | no MR -> candidate analysis |
| GRAM domain-containing protein 1C levels (GRAMD1C.8842.16.3) | 3e-148 | rs61077924 | 4 | GCST90241314 | no MR -> candidate analysis |
| Blood protein levels | 4e-133 | rs4422272 | 1 | GCST006585 | no MR -> candidate analysis |
| CD200R1 protein levels | 5e-45 | rs564438696 | 2 | GCST90468605 | no MR -> candidate analysis |
| 3-hydroxypropylmercapturic acid levels in smokers | 8e-8 | rs114780919 | 1 | GCST002956 | no MR -> candidate analysis |
| Urinary uromodulin levels (raw) | 1e-6 | rs139248026 | 1 | GCST90103502 | no MR -> candidate analysis |
| Lateral ventricle temporal horn volume | 3e-6 | rs73230239 | 1 | GCST009218 | no MR -> candidate analysis |
| Stuttering | 5e-6 | rs145711937 | 1 | GCST90707223 | no MR -> candidate analysis |
| 5-HETrE levels in elite athletes | 7e-6 | rs6438172 | 1 | GCST90133836 | no MR -> candidate analysis |
| Prospective and Retrospective Memory Questionnaire (PRMQ) Re | 7e-6 | rs6798319 | 1 | GCST90448158 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 337 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| gastritis | 0.393 | — | common-variant locus | MR: beta=-0.0187, p=0.491 (cis) |
| myocardial ischemia | 0.324 | — | common-variant locus | no MR -> candidate analysis |
Of the 2 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Protein Aster-C) |
| gnomAD constraint | pLI=8.7e-28, LOEUF=1.09 — LoF-tolerant |
| GWAS Catalog | 23 unique SNPs / 46 rows |
| ClinVar | 134 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 337 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘GRAMD1C’ and resolved to ‘Protein Aster-C’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 134 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 11 of 11 traits by best p-value, aggregated from 21 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8IYS0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000178075/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6067584/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/GRAMD1C — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GRAMD1C — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GRAMD1C%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GRAMD1C — GWAS Catalog search API (live; release not exposed)