MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 0.181 | 0.0541 | 8.20e-04 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema | 0.117 | 0.0358 | 0.00102 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R35 Polyuria | 0.303 | 0.108 | 0.00511 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.0933 | 0.0339 | 0.00593 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.138 | 0.0502 | 0.0061 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) | 0.225 | 0.0957 | 0.0186 | Wald ratio | 1 | trans | NA |
| Fractured bone site(s): Wrist | -0.182 | 0.0779 | 0.0196 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | 0.164 | 0.0731 | 0.0247 | Wald ratio | 1 | trans | NA |
| Weight | 0.0174 | 0.00798 | 0.0297 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | 0.133 | 0.0621 | 0.0324 | Wald ratio | 1 | trans | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.0461 | 0.0227 | 0.0425 | Inverse variance weighted | 2 | trans | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.0461 | 0.0227 | 0.0425 | Inverse variance weighted | 2 | trans | NA |
| …and 103 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
103 association rows across 67 traits (64 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 5e-34 | rs62311172 | 2 | GCST90321120 | no MR -> candidate analysis |
| CCER2 protein levels | 8e-29 | rs17021163 | 1 | GCST90468563 | no MR -> candidate analysis |
| Height | 9e-28 | rs1503211 | 2 | GCST90245848 | MR: beta=0.0174, p=0.129 (trans) |
| Smoking initiation | 9e-25 | rs1503212 | 9 | GCST90243985 | no MR -> candidate analysis |
| Body mass index | 4e-19 | rs6532412 | 9 | GCST90662912 | MR: beta=0.00729, p=0.42 (trans) |
| Educational attainment | 9e-17 | rs1972863 | 4 | GCST90105038 | no MR -> candidate analysis |
| Weight | 7e-16 | rs6532412 | 2 | GCST90662910 | MR: beta=0.0174, p=0.0297 (trans) |
| HPGDS protein levels | 2e-14 | rs10022274 | 2 | GCST90469472 | no MR -> candidate analysis |
| Educational attainment (MTAG) | 4e-14 | rs12503522 | 2 | GCST006571 | no MR -> candidate analysis |
| Educational attainment (years of education) | 4e-13 | rs12503522 | 2 | GCST006442 | no MR -> candidate analysis |
| Gut microbial network clusters (Salmon (at 1 year) x Any Bre | 4e-13 | rs74450133 | 1 | GCST90569450 | no MR -> candidate analysis |
| Smoking initiation (ever regular vs never regular) (MTAG) | 6e-13 | rs1160685 | 2 | GCST007468 | no MR -> candidate analysis |
| …and 55 more traits (see JSON) |
Top diseases by Open Targets association (of 2155 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 18 | 0.845 | — | established (curated) | no MR -> candidate analysis |
| Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency | 0.73 | — | established (curated) | no MR -> candidate analysis |
| hereditary disease | 0.774 | — | established (curated) | no MR -> candidate analysis |
| diabetes mellitus | 0.576 | — | common-variant locus | no MR -> candidate analysis |
| facial pain | 0.562 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.516 | — | common-variant locus | no MR -> candidate analysis |
| dementia | 0.503 | — | common-variant locus | no MR -> candidate analysis |
| eye disorder | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| polyp of colon | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.483 | — | common-variant locus | no MR -> candidate analysis |
| stricture | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| smoking cessation | 0.477 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.471 | — | common-variant locus | MR: beta=-0.0389, p=0.419 (trans) |
| colorectal carcinoma | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.406 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Glutamate (NMDA/AMPA/Kainate)) |
| gnomAD constraint | pLI=1, LOEUF=0.384 — LoF-INTOLERANT |
| GWAS Catalog | 94 unique SNPs / 188 rows |
| ClinVar | 408 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 2155 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘GRID2’ and resolved to ‘Glutamate (NMDA/AMPA/Kainate)’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 408 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 67 traits by best p-value, aggregated from 103 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O43424 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000152208/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4524129/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/GRID2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GRID2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GRID2%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=GRID2 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/GRID2 — GWAS Catalog search API (live; release not exposed)