Protein Dossier — GSTP1 (Glutathione S-transferase P)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
0.0535 |
0.0125 |
1.79e-05 |
Wald ratio |
1 |
cis |
NA |
| Mean cell volume |
0.612 |
0.153 |
6.14e-05 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin |
0.217 |
0.0601 |
2.98e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis |
0.245 |
0.072 |
6.45e-04 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
-0.449 |
0.169 |
0.00795 |
Wald ratio |
1 |
cis |
NA |
| Knee osteoarthritis |
0.407 |
0.154 |
0.00822 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.0252 |
0.011 |
0.0222 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] |
0.193 |
0.0846 |
0.0222 |
Wald ratio |
1 |
cis |
NA |
| Red blood cell count |
-0.0281 |
0.0129 |
0.0297 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: depression |
0.113 |
0.0522 |
0.0305 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0773 |
0.0367 |
0.0351 |
Wald ratio |
1 |
cis |
NA |
| Percent emphysema |
-0.222 |
0.111 |
0.045 |
Wald ratio |
1 |
cis |
NA |
| …and 104 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4911_49_2 |
Glutathione S-transferase Pi |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
30 association rows across 26 traits (29 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Glutathione S-transferase P (analyte X4911.49) levels |
5e-315 |
rs1695 |
1 |
GCST90426141 |
no MR -> candidate analysis |
| Circulating GSTP1 levels |
1e-217 |
rs7927657 |
2 |
GCST90860696 |
no MR -> candidate analysis |
| GSTP1 protein levels |
1e-210 |
rs762803 |
2 |
GCST90469414 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
3e-192 |
rs6591250 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| Height (baseline) |
7e-43 |
rs145044531 |
1 |
GCST90565843 |
no MR -> candidate analysis |
| Glutathione S-transferase P levels |
4e-39 |
rs11227841 |
1 |
GCST90247750 |
no MR -> candidate analysis |
| N-acetylglycine levels |
4e-29 |
rs640777 |
3 |
GCST90245320 |
no MR -> candidate analysis |
| Cis-3,4-methyleneheptanoylglycine levels |
4e-20 |
rs596603 |
1 |
GCST90200274 |
no MR -> candidate analysis |
| Hip circumference adjusted for BMI |
7e-17 |
rs36051467 |
1 |
GCST012227 |
no MR -> candidate analysis |
| 2-butenoylglycine levels |
3e-16 |
rs596603 |
1 |
GCST90200152 |
no MR -> candidate analysis |
| Glutathione S-transferase P level in Chronic kidney disease |
8e-15 |
rs1695 |
1 |
GCST90237743 |
no MR -> candidate analysis |
| Metabolite levels (N-acetyltryptophan) |
2e-14 |
rs35297589 |
1 |
GCST90300142 |
no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 760 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| connective tissue neoplasm |
0.21 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Glutathione S-transferase P) |
| gnomAD constraint |
pLI=8.2e-10, LOEUF=1.3 — LoF-tolerant |
| GWAS Catalog |
72 unique SNPs / 144 rows |
| ClinVar |
83 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
22 clinical annotations across 17 drugs |
phenome — Top 30 of 760 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘GSTP1’ and resolved to ‘Glutathione S-transferase P’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 83 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 30 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P09211 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000084207/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3902/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/GSTP1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GSTP1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GSTP1%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=GSTP1 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/GSTP1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:56:19 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none