MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Neuroticism | 0.0395 | 0.0186 | 0.0336 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: uterine fibroids | -0.244 | 0.119 | 0.041 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | -0.577 | 0.293 | 0.0488 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | 0.152 | 0.0823 | 0.0651 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee | -0.155 | 0.0901 | 0.0865 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K43 Ventral hernia | 0.236 | 0.138 | 0.0871 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Ankle | 0.144 | 0.0848 | 0.0897 | Wald ratio | 1 | cis | NA |
| Invasive mucinous ovarian cancer | -0.312 | 0.186 | 0.0929 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.049 | 0.0293 | 0.0945 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.144 | 0.0927 | 0.119 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | 0.0325 | 0.0209 | 0.12 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | -0.338 | 0.221 | 0.125 | Wald ratio | 1 | cis | NA |
| …and 53 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
4 association rows across 4 traits (1 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Total protein levels x insomnia interaction | 1e-10 | rs76360971 | 1 | GCST90026658 | no MR -> candidate analysis |
| Gut microbial network clusters (Salmon (at 1 year) x Househo | 1e-7 | rs6510836 | 1 | GCST90569455 | no MR -> candidate analysis |
| Gut microbial network clusters (Salmon (at 1 year) x Househo | 2e-7 | rs6510836 | 1 | GCST90569451 | no MR -> candidate analysis |
| Response to antidepressants (symptom improvement) in major d | 5e-6 | rs111763479 | 1 | GCST90244558 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 122 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| tooth disorder | 0.359 | — | common-variant locus | no MR -> candidate analysis |
| insomnia | 0.042 | — | common-variant locus | no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Granzyme M) |
| gnomAD constraint | pLI=1.1e-09, LOEUF=1.69 — LoF-tolerant |
| GWAS Catalog | 32 unique SNPs / 64 rows |
| ClinVar | 89 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 122 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘GZMM’ and resolved to ‘Granzyme M’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 89 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 4 of 4 traits by best p-value, aggregated from 4 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P51124 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000197540/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4523234/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/GZMM — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GZMM — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GZMM%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GZMM — GWAS Catalog search API (live; release not exposed)