MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Triglycerides | -0.05 | 0.0143 | 4.84e-04 | Wald ratio | 1 | trans | NA |
| Urate | -0.0549 | 0.0165 | 8.58e-04 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | 0.155 | 0.0554 | 0.00514 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: gout | -0.21 | 0.0777 | 0.00679 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation | 0.115 | 0.0464 | 0.0135 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | 0.133 | 0.0553 | 0.0164 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R55 Syncope and collapse | 0.161 | 0.0677 | 0.0177 | Wald ratio | 1 | trans | NA |
| 2hr glucose | 0.137 | 0.0579 | 0.0179 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: migraine | 0.0859 | 0.0396 | 0.0301 | Wald ratio | 1 | trans | NA |
| Chronic kidney disease | -0.0975 | 0.0457 | 0.0329 | Wald ratio | 1 | trans | NA |
| Nucleus accumbens volume | -6.98 | 3.28 | 0.033 | Wald ratio | 1 | trans | NA |
| Body mass index (BMI) | 0.0158 | 0.00745 | 0.0345 | Wald ratio | 1 | trans | NA |
| …and 111 more outcomes (see JSON) |
| Dataset | Trait | Author | Year |
|---|---|---|---|
prot-c-3332_57_1 |
RGM-C | Suhre K | 2019 |
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 224 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hemochromatosis type 2A | 0.955 | — | established (curated) | no MR -> candidate analysis |
| hemochromatosis type 2 | 0.657 | — | established (curated) | no MR -> candidate analysis |
| hemochromatosis type 1 | 0.684 | — | established (curated) | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.14 | — | common-variant locus | no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | not available |
| GWAS Catalog | no mapped SNPs |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 224 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘HFE2’.gnomad — No gnomAD constraint data.gwas — No GWAS Catalog SNPs mapped to this gene.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/Q6ZVN8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000168509/associations — Open Targets data release 26.06