Protein Dossier — HGF (Hepatocyte growth factor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypopituitarism |
1.03 |
0.312 |
9.90e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: retinal detachment |
0.481 |
0.16 |
0.00262 |
Wald ratio |
1 |
cis |
NA |
| Age at menarche |
0.0978 |
0.0355 |
0.0058 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoporosis |
0.24 |
0.0916 |
0.00879 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb |
0.222 |
0.0883 |
0.0118 |
Wald ratio |
1 |
cis |
NA |
| Fasting insulin |
-0.0412 |
0.0185 |
0.0263 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.261 |
0.118 |
0.0264 |
Wald ratio |
1 |
cis |
NA |
| HOMA-IR |
-0.0515 |
0.0237 |
0.0297 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.144 |
0.0685 |
0.0353 |
Wald ratio |
1 |
cis |
NA |
| Small vessel disease |
0.453 |
0.219 |
0.0389 |
Wald ratio |
1 |
cis |
NA |
| Forearm bone mineral density |
0.181 |
0.0925 |
0.0501 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: joint disorder |
0.307 |
0.159 |
0.0534 |
Wald ratio |
1 |
cis |
NA |
| …and 84 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2681_23_2 |
HGF |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
118 association rows across 67 traits (99 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating HGF levels (id: OID00522_OID20656) |
3e-81 |
rs5745687 |
4 |
GCST90859878 |
no MR -> candidate analysis |
| Circulating HGF levels (id: OID00706_OID20656) |
5e-59 |
rs5745687 |
4 |
GCST90860049 |
no MR -> candidate analysis |
| Circulating HGF levels (id: OID00803_OID20656) |
3e-56 |
rs5745687 |
4 |
GCST90860133 |
no MR -> candidate analysis |
| HGF protein levels |
4e-52 |
rs5745687 |
2 |
GCST90469449 |
no MR -> candidate analysis |
| Facial appearance |
3e-35 |
rs28584384 |
1 |
GCST90128425 |
no MR -> candidate analysis |
| Hepatocyte growth factor levels |
9e-35 |
rs554133413 |
12 |
GCST90247875 |
no MR -> candidate analysis |
| Sex hormone-binding globulin levels adjusted for BMI |
1e-32 |
rs1229492 |
4 |
GCST90012110 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein HGF levels |
3e-31 |
rs10252734 |
1 |
GCST90943462 |
no MR -> candidate analysis |
| Sex hormone-binding globulin levels |
9e-27 |
rs1229492 |
10 |
GCST90012111 |
no MR -> candidate analysis |
| Unsupervised deep imaging phenotypes (UDIP-FA) |
2e-20 |
rs10252734 |
1 |
GCST90860937 |
no MR -> candidate analysis |
| Glycoprotein acetyls levels |
3e-20 |
rs1229480 |
2 |
GCST90501111 |
no MR -> candidate analysis |
| Endothelial growth factor levels |
4e-19 |
rs5745687 |
1 |
GCST002731 |
no MR -> candidate analysis |
| …and 55 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2009 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hearing loss, autosomal recessive |
0.744 |
— |
established (curated) |
no MR -> candidate analysis |
| prostate carcinoma |
0.53 |
— |
common-variant locus |
no MR -> candidate analysis |
| kidney disorder |
0.59 |
— |
common-variant locus |
no MR -> candidate analysis |
| Sensorineural hearing impairment |
0.559 |
— |
established (curated) |
no MR -> candidate analysis |
| ovarian neoplasm |
0.499 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 5 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
20 known modulators (Hepatocyte growth factor receptor) |
| gnomAD constraint |
pLI=1, LOEUF=0.456 — LoF-INTOLERANT |
| GWAS Catalog |
52 unique SNPs / 104 rows |
| ClinVar |
356 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 2009 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘HGF’ and resolved to ‘Hepatocyte growth factor receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 356 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 67 traits by best p-value, aggregated from 118 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P14210 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000019991/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3717/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/HGF — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/HGF — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=HGF%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/HGF — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:00:00 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none