MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Age at menarche | -0.0546 | 0.0131 | 3.10e-05 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] | 0.139 | 0.041 | 7.00e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0292 | 0.00935 | 0.00178 | Wald ratio | 1 | cis | NA |
| Birth weight | 0.0248 | 0.00842 | 0.00322 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | -0.225 | 0.0849 | 0.00799 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.0947 | 0.0359 | 0.00831 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0144 | 0.00578 | 0.0129 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | -0.0681 | 0.0284 | 0.0166 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bone disorder | -0.484 | 0.206 | 0.0186 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | -0.0892 | 0.0389 | 0.0218 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting | 0.173 | 0.0761 | 0.0228 | Wald ratio | 1 | cis | NA |
| HDL cholesterol | 0.0241 | 0.0111 | 0.0305 | Wald ratio | 1 | cis | NA |
| …and 100 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
24 association rows across 16 traits (19 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating HPGDS levels | 2e-1121 | rs7438414 | 4 | GCST90860315 | no MR -> candidate analysis |
| Hematopoietic prostaglandin D synthase levels | 3e-244 | rs6532479 | 2 | GCST90247924 | no MR -> candidate analysis |
| Serum levels of protein HPGDS | 2e-113 | rs72665697 | 2 | GCST90087062 | no MR -> candidate analysis |
| Hematopoietic prostaglandin D synthase levels (HPGDS.12549.3 | 1e-71 | rs1965049 | 2 | GCST90241378 | no MR -> candidate analysis |
| Blood protein levels | 4e-59 | rs11097414 | 1 | GCST006585 | no MR -> candidate analysis |
| Hematopoietic prostaglandin D synthase level in Chronic kidn | 3e-30 | rs116304230 | 1 | GCST90233535 | no MR -> candidate analysis |
| Menarche (age at onset) | 2e-18 | rs7438414 | 1 | GCST007078 | no MR -> candidate analysis |
| QT interval | 5e-15 | rs10028613 | 1 | GCST90179153 | no MR -> candidate analysis |
| HPGDS protein levels | 4e-13 | rs9762154 | 1 | GCST90469472 | no MR -> candidate analysis |
| Male puberty timing (age at voice breaking MTAG) | 2e-11 | rs767657 | 1 | GCST90012088 | no MR -> candidate analysis |
| Testicular germ cell tumor | 1e-8 | rs17021463 | 3 | GCST002023 | no MR -> candidate analysis |
| Substantia nigra iron levels (quantitative susceptibility ma | 2e-8 | rs10516950 | 1 | GCST90551871 | no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
Top diseases by Open Targets association (of 957 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| glaucoma | 0.618 | — | common-variant locus | MR: beta=0.0498, p=0.268 (cis) |
| open-angle glaucoma | 0.576 | — | common-variant locus | no MR -> candidate analysis |
| testicular cancer | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| Proptosis | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| spinal stenosis | 0.504 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.47 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.413 | — | common-variant locus | no MR -> candidate analysis |
| prostate carcinoma | 0.081 | — | common-variant locus | no MR -> candidate analysis |
| cancer | 0.038 | — | common-variant locus | MR: beta=0.0292, p=0.00178 (cis) |
| prostate cancer | 0.069 | — | common-variant locus | MR: beta=-0.136, p=0.074 (cis) |
| alcohol drinking | 0.072 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.072 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Hematopoietic prostaglandin D synthase) |
| gnomAD constraint | pLI=2e-10, LOEUF=1.56 — LoF-tolerant |
| GWAS Catalog | 59 unique SNPs / 118 rows |
| ClinVar | 55 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 957 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘HPGDS’ and resolved to ‘Hematopoietic prostaglandin D synthase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 55 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 24 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O60760 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163106/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5879/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/HPGDS — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/HPGDS — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=HPGDS%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/HPGDS — GWAS Catalog search API (live; release not exposed)