Protein Dossier — HPX (Hemopexin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Cardioembolic stroke |
-0.14 |
0.0524 |
0.00774 |
Inverse variance weighted |
2 |
cis |
NA |
| Cardioembolic stroke |
-0.14 |
0.0524 |
0.00774 |
Inverse variance weighted |
2 |
trans |
NA |
| Systolic blood pressure automated reading |
0.00943 |
0.00366 |
0.00995 |
Inverse variance weighted |
2 |
cis |
NA |
| Systolic blood pressure automated reading |
0.00943 |
0.00366 |
0.00995 |
Inverse variance weighted |
2 |
trans |
NA |
| Diastolic blood pressure automated reading |
0.00936 |
0.00366 |
0.0105 |
Inverse variance weighted |
2 |
cis |
NA |
| Diastolic blood pressure automated reading |
0.00936 |
0.00366 |
0.0105 |
Inverse variance weighted |
2 |
trans |
NA |
| Weight |
0.0076 |
0.00316 |
0.016 |
Inverse variance weighted |
2 |
cis |
NA |
| Weight |
0.0076 |
0.00316 |
0.016 |
Inverse variance weighted |
2 |
trans |
NA |
| Body mass index (BMI) |
0.0084 |
0.00357 |
0.0186 |
Inverse variance weighted |
2 |
cis |
NA |
| Body mass index (BMI) |
0.0084 |
0.00357 |
0.0186 |
Inverse variance weighted |
2 |
trans |
NA |
| Internalizing problems |
-0.0946 |
0.0407 |
0.02 |
Wald ratio |
1 |
trans |
NA |
| Mean cell volume |
-0.112 |
0.05 |
0.0247 |
Wald ratio |
1 |
trans |
NA |
| …and 148 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2768_56_2 |
Hemopexin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
48 association rows across 43 traits (48 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| GTPase KRas levels |
5e-88 |
rs76881753 |
1 |
GCST90137602 |
no MR -> candidate analysis |
| Muellerian-inhibiting factor levels |
7e-64 |
rs35862450 |
3 |
GCST90248474 |
no MR -> candidate analysis |
| Syntaxin-17 level in Chronic kidney disease with hypertensio |
1e-54 |
rs12117 |
1 |
GCST90235794 |
no MR -> candidate analysis |
| Apolipoprotein L1 level in Chronic kidney disease with hyper |
2e-50 |
rs12117 |
1 |
GCST90239378 |
no MR -> candidate analysis |
| Tumor necrosis factor ligand superfamily member 18 level in |
4e-48 |
rs12117 |
1 |
GCST90237057 |
no MR -> candidate analysis |
| Core-binding factor subunit beta level in Chronic kidney dis |
8e-48 |
rs12117 |
1 |
GCST90232819 |
no MR -> candidate analysis |
| Exportin-5 level in Chronic kidney disease with hypertension |
2e-47 |
rs12117 |
1 |
GCST90237001 |
no MR -> candidate analysis |
| SMPD1/SMPDL3A protein level ratio |
2e-45 |
rs35274104 |
1 |
GCST90315854 |
no MR -> candidate analysis |
| NTF2-related export protein 2 level in Chronic kidney diseas |
4e-44 |
rs12117 |
1 |
GCST90235181 |
no MR -> candidate analysis |
| Tumor necrosis factor level in Chronic kidney disease with h |
1e-39 |
rs12117 |
1 |
GCST90238125 |
no MR -> candidate analysis |
| Homeobox protein SIX6 level in Chronic kidney disease with h |
1e-35 |
rs12117 |
1 |
GCST90235543 |
no MR -> candidate analysis |
| Tumor necrosis factor ligand superfamily member 18 levels |
1e-34 |
rs77296242 |
1 |
GCST90161439 |
no MR -> candidate analysis |
| …and 31 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 697 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| panniculitis |
0.353 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Hemopexin) |
| gnomAD constraint |
pLI=9.1e-12, LOEUF=1.01 — LoF-tolerant |
| GWAS Catalog |
54 unique SNPs / 108 rows |
| ClinVar |
120 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 697 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘HPX’ and resolved to ‘Hemopexin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 120 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 43 traits by best p-value, aggregated from 48 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P02790 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000110169/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2176811/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/HPX — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/HPX — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=HPX%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/HPX — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:02:29 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none