MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Heel bone mineral density (BMD) T-score automated | -0.0114 | 0.00308 | 2.26e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: sleep apnoea | -0.161 | 0.0505 | 0.00149 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.00581 | 0.00186 | 0.00179 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) | 0.048 | 0.0161 | 0.00284 | Wald ratio | 1 | cis | NA |
| Crohn’s disease | -0.0338 | 0.0124 | 0.00618 | Wald ratio | 1 | cis | NA |
| Chronic kidney disease | 0.0392 | 0.0146 | 0.0072 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | -0.0267 | 0.0101 | 0.00786 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.00611 | 0.00234 | 0.00906 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis | 0.0812 | 0.0322 | 0.0115 | Wald ratio | 1 | cis | NA |
| Inflammatory bowel disease | -0.025 | 0.0102 | 0.0142 | Wald ratio | 1 | cis | NA |
| Knee osteoarthritis | 0.0564 | 0.0271 | 0.0374 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | -0.0656 | 0.0332 | 0.048 | Wald ratio | 1 | cis | NA |
| …and 99 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
30 association rows across 22 traits (29 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Endoplasmin levels (HSP90B1.6393.63.3) | 4e-795 | rs1165693 | 1 | GCST90241048 | no MR -> candidate analysis |
| Endoplasmin levels | 2e-250 | rs1177457 | 2 | GCST90426673 | no MR -> candidate analysis |
| Potassium voltage-gated channel subfamily A member 10 levels | 7e-240 | rs1177457 | 2 | GCST90422054 | no MR -> candidate analysis |
| HSP90B1 protein levels | 7e-166 | rs1177457 | 4 | GCST90453183 | no MR -> candidate analysis |
| Serum levels of protein HSP90B1 | 7e-156 | rs2583273 | 1 | GCST90089394 | no MR -> candidate analysis |
| Endoplasmin level in Chronic kidney disease with hypertensio | 1e-106 | rs1165692 | 1 | GCST90238248 | no MR -> candidate analysis |
| Serum levels of protein HNRNPM | 6e-103 | rs1165683 | 1 | GCST90087223 | no MR -> candidate analysis |
| Height | 8e-47 | rs4964375 | 2 | GCST90245848 | MR: beta=0.00328, p=0.261 (cis) |
| Paralemmin-1 protein levels (SomaScan ID:6393-63) | 1e-37 | rs1177457 | 1 | GCST90443384 | no MR -> candidate analysis |
| Heterogeneous nuclear ribonucleoprotein M levels | 9e-24 | rs1165695 | 1 | GCST90247916 | no MR -> candidate analysis |
| Leucine-rich repeat, immunoglobulin-like domain and transmem | 2e-23 | rs3830654 | 1 | GCST90248331 | no MR -> candidate analysis |
| CRELD2 protein levels | 8e-21 | rs2583273 | 1 | GCST90468859 | no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
Top diseases by Open Targets association (of 449 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Dysmetria | 0.401 | — | common-variant locus | no MR -> candidate analysis |
| venous thromboembolism | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| diverticular disease | 0.378 | — | common-variant locus | MR: beta=-0.0387, p=0.0982 (cis) |
| atrial septal defect | 0.309 | — | common-variant locus | no MR -> candidate analysis |
Of the 4 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Endoplasmin) |
| gnomAD constraint | pLI=1, LOEUF=0.371 — LoF-INTOLERANT |
| GWAS Catalog | 66 unique SNPs / 129 rows |
| ClinVar | 134 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 449 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘HSP90B1’ and resolved to ‘Endoplasmin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 134 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 30 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P14625 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000166598/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1075323/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/HSP90B1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/HSP90B1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=HSP90B1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/HSP90B1 — GWAS Catalog search API (live; release not exposed)