Protein Dossier — ICAM1 (Intercellular adhesion molecule 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diastolic blood pressure automated reading |
0.00759 |
0.00204 |
2.02e-04 |
Inverse variance weighted |
3 |
cis |
NA |
| Diastolic blood pressure automated reading |
0.00759 |
0.00204 |
2.02e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Diastolic blood pressure automated reading |
0.00759 |
0.00204 |
2.02e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: hypertension |
0.00324 |
0.000884 |
2.49e-04 |
Inverse variance weighted |
3 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.00324 |
0.000884 |
2.49e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: hypertension |
0.00324 |
0.000884 |
2.49e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Neo-extraversion |
0.219 |
0.0683 |
0.00134 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
-0.0015 |
0.00047 |
0.0014 |
Inverse variance weighted |
3 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
-0.0015 |
0.00047 |
0.0014 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
-0.0015 |
0.00047 |
0.0014 |
Inverse variance weighted |
3 |
trans |
NA |
| Body mass index (BMI) |
0.00561 |
0.00199 |
0.0049 |
Inverse variance weighted |
3 |
cis |
NA |
| Body mass index (BMI) |
0.00561 |
0.00199 |
0.0049 |
Inverse variance weighted |
3 |
trans |
NA |
| …and 279 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4342_10_3 |
sICAM-1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
88 association rows across 34 traits (84 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Intercellular adhesion molecule 1 levels |
2e-5507 |
rs5498 |
15 |
GCST90248103 |
no MR -> candidate analysis |
| Intercellular adhesion molecule 1 levels (ICAM1.4342.10.3) |
8e-1683 |
rs5498 |
1 |
GCST90241537 |
no MR -> candidate analysis |
| Circulating ICAM1 levels |
3e-919 |
rs12462944 |
4 |
GCST90860432 |
no MR -> candidate analysis |
| ICAM1 protein levels |
2e-184 |
rs139053442 |
10 |
GCST90469498 |
no MR -> candidate analysis |
| Soluble ICAM-1 |
1e-120 |
rs1799969 |
6 |
GCST001047 |
no MR -> candidate analysis |
| Lymphocyte count |
6e-107 |
rs5498 |
5 |
GCST90002316 |
no MR -> candidate analysis |
| ICAM4 protein levels |
2e-96 |
rs5030377 |
1 |
GCST90469501 |
no MR -> candidate analysis |
| Intercellular adhesion molecule 5 levels (ICAM5.8245.27.3) |
8e-86 |
rs75407602 |
1 |
GCST90241541 |
no MR -> candidate analysis |
| Lymphocyte count (UKB data field 30120) |
1e-77 |
rs5498 |
1 |
GCST90468082 |
no MR -> candidate analysis |
| ICAM5 protein levels |
3e-76 |
rs76923681 |
3 |
GCST90469502 |
no MR -> candidate analysis |
| Intercellular adhesion molecule 1 level in Chronic kidney di |
5e-64 |
rs5498 |
1 |
GCST90237630 |
no MR -> candidate analysis |
| Intercellular adhesion molecule 5 levels |
3e-53 |
rs923366 |
4 |
GCST90137725 |
no MR -> candidate analysis |
| …and 22 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1944 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| atrial fibrillation |
0.641 |
— |
common-variant locus |
MR: beta=0.000365, p=0.088 (cis) |
| vascular disorder |
0.556 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.494 |
— |
common-variant locus |
no MR -> candidate analysis |
| cardiac arrhythmia |
0.494 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial flutter |
0.491 |
— |
common-variant locus |
MR: beta=0.000365, p=0.088 (cis) |
| lymphatic system disorder |
0.347 |
0.337 |
multi-layer: burden+GWAS (allelic-series candidate) |
no MR -> candidate analysis |
| Abnormality of the lymphatic system |
0.337 |
0.337 |
exploratory rare-variant signal |
no MR -> candidate analysis |
| inflammatory bowel disease |
0.141 |
— |
common-variant locus |
MR: beta=-0.0142, p=0.108 (cis) |
Of the 8 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 1 exploratory rare-variant signal(s), 1 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
3 known modulators (Intercellular adhesion molecule 1) |
| gnomAD constraint |
pLI=9.2e-07, LOEUF=0.907 — LoF-tolerant |
| GWAS Catalog |
163 unique SNPs / 406 rows |
| ClinVar |
118 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1944 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ICAM1’ and resolved to ‘Intercellular adhesion molecule 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 118 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 34 traits by best p-value, aggregated from 88 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P05362 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000090339/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3070/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ICAM1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ICAM1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ICAM1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ICAM1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:04:13 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none