Protein Dossier — ICAM5 (Intercellular adhesion molecule 5)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Crohn’s disease |
0.0884 |
0.017 |
1.85e-07 |
Wald ratio |
1 |
cis |
0.988 |
| Inflammatory bowel disease |
0.0732 |
0.0141 |
2.03e-07 |
Wald ratio |
1 |
cis |
0.0338 |
| Ulcerative colitis |
0.0592 |
0.0177 |
8.35e-04 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
-0.115 |
0.0413 |
0.00544 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: high cholesterol |
-0.025 |
0.00905 |
0.00575 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
-0.0143 |
0.00564 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
-0.0101 |
0.00449 |
0.0244 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.0615 |
0.0289 |
0.0333 |
Wald ratio |
1 |
cis |
NA |
| PGC cross-disorder traits |
0.0397 |
0.0196 |
0.0433 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
18.5 |
9.29 |
0.046 |
Wald ratio |
1 |
cis |
NA |
| Happiness |
0.00797 |
0.00405 |
0.049 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
-0.0788 |
0.0401 |
0.0494 |
Wald ratio |
1 |
cis |
NA |
| …and 81 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5124_69_3 |
sICAM-5 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
53 association rows across 36 traits (50 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Blood protein levels |
6e-614 |
rs901886 |
1 |
GCST006585 |
no MR -> candidate analysis |
| ICAM5 protein levels |
2e-305 |
rs187486291 |
4 |
GCST90469502 |
no MR -> candidate analysis |
| Circulating ICAM1 levels |
4e-271 |
rs35318566 |
2 |
GCST90860432 |
no MR -> candidate analysis |
| Intercellular adhesion molecule 5 levels |
1e-266 |
rs2569703 |
4 |
GCST90248107 |
no MR -> candidate analysis |
| Intercellular adhesion molecule 5 levels (ICAM5.8245.27.3) |
2e-171 |
rs901886 |
2 |
GCST90241541 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
3e-117 |
rs2075742 |
3 |
GCST90838669 |
no MR -> candidate analysis |
| Protein quantitative trait loci |
5e-108 |
rs12150978 |
2 |
GCST010900 |
no MR -> candidate analysis |
| Lymphocyte count |
3e-63 |
rs150434441 |
1 |
GCST90018962 |
no MR -> candidate analysis |
| EGF-like repeat and discoidin I-like domain-containing prote |
6e-60 |
rs885743 |
1 |
GCST90442905 |
no MR -> candidate analysis |
| Lymphocyte percentage (UKB data field 30180) |
6e-42 |
rs2569703 |
1 |
GCST90468083 |
no MR -> candidate analysis |
| Platelet-to-lymphocyte ratio |
4e-31 |
rs12972990 |
1 |
GCST90056184 |
no MR -> candidate analysis |
| Neutrophil-to-lymphocyte ratio |
2e-29 |
rs2569703 |
3 |
GCST90866310 |
no MR -> candidate analysis |
| …and 24 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 147 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| inflammatory bowel disease |
0.534 |
— |
common-variant locus |
MR: beta=0.0732, p=2.03e-07 (cis) |
| Eczematoid dermatitis |
0.502 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypertensive disorder |
0.374 |
— |
common-variant locus |
no MR -> candidate analysis |
| vascular disorder |
0.294 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial fibrillation |
0.272 |
— |
common-variant locus |
no MR -> candidate analysis |
| cardiac arrhythmia |
0.256 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.256 |
— |
common-variant locus |
no MR -> candidate analysis |
| rheumatoid arthritis |
0.233 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial flutter |
0.235 |
— |
common-variant locus |
no MR -> candidate analysis |
| COVID-19 |
0.213 |
— |
common-variant locus |
no MR -> candidate analysis |
| Crohn disease |
0.215 |
— |
common-variant locus |
no MR -> candidate analysis |
| skin disorder |
0.216 |
— |
common-variant locus |
no MR -> candidate analysis |
| psoriasis |
0.172 |
— |
common-variant locus |
MR: beta=0.0615, p=0.0333 (cis) |
| autoimmune disease |
0.181 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 1 diabetes mellitus |
0.172 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.00035, LOEUF=0.632 — LoF-tolerant |
| GWAS Catalog |
166 unique SNPs / 402 rows |
| ClinVar |
109 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 147 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ICAM5’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 109 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 36 traits by best p-value, aggregated from 53 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UMF0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000105376/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ICAM5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ICAM5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ICAM5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ICAM5 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:04:32 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none