MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: uterine fibroids | -0.311 | 0.117 | 0.0081 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse | 0.285 | 0.108 | 0.00858 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.154 | 0.063 | 0.0145 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: small intestine or small bowel cancer | 0.661 | 0.28 | 0.0181 | Wald ratio | 1 | cis | NA |
| Subjective well being | 0.028 | 0.012 | 0.0196 | Wald ratio | 1 | cis | NA |
| Height | 0.0284 | 0.0136 | 0.0368 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | -0.0895 | 0.0435 | 0.0395 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate | -0.294 | 0.15 | 0.0504 | Wald ratio | 1 | cis | NA |
| Fasting insulin | -0.0288 | 0.0152 | 0.0581 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | 0.142 | 0.0764 | 0.0635 | Wald ratio | 1 | cis | NA |
| Fracture resulting from simple fall | -0.0523 | 0.029 | 0.0712 | Wald ratio | 1 | cis | NA |
| Age at menarche | -0.048 | 0.0268 | 0.073 | Wald ratio | 1 | cis | NA |
| …and 77 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
8 association rows across 8 traits (6 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status | |
|---|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase 1 levels (IDO1.9759.13.3) | 3e-20 | rs7010461 | 1 | GCST90241490 | no MR -> candidate analysis | |
| IDO1 protein levels | 2e-16 | rs146413896 | 1 | GCST90469506 | no MR -> candidate analysis | |
| Quinolinate levels | 4e-13 | rs7000868 | 1 | GCST90103166 | no MR -> candidate analysis | |
| Kynurenine levels | 5e-13 | rs62512638 | 1 | GCST90103029 | no MR -> candidate analysis | |
| Facial morphology (D332) | 8e-10 | rs59547557 | 1 | GCST90302914 | no MR -> candidate analysis | |
| Caproate (6:0) levels | 4e-8 | rs561468024 | 1 | GCST90245132 | no MR -> candidate analysis | |
| Vaginal microbiome MetaCyc pathway (PWY-6708 | ubiquinol-8 bio | 6e-7 | rs79183354 | 1 | GCST90026888 | no MR -> candidate analysis |
| Vaginal microbiome MetaCyc pathway (UBISYN-PWY | superpathway | 9e-6 | rs79183354 | 1 | GCST90026980 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 1153 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| stomach disorder | 0.438 | — | common-variant locus | no MR -> candidate analysis |
| facial morphology | 0.319 | — | common-variant locus | no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 2 known modulators (Indoleamine 2,3-dioxygenase 1) |
| gnomAD constraint | pLI=1.9e-11, LOEUF=1.2 — LoF-tolerant |
| GWAS Catalog | 23 unique SNPs / 46 rows |
| ClinVar | 136 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 2 drugs |
phenome — Top 30 of 1153 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IDO1’ and resolved to ‘Indoleamine 2,3-dioxygenase 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 136 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 8 of 8 traits by best p-value, aggregated from 8 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P14902 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000131203/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4685/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IDO1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IDO1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IDO1%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=IDO1 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/IDO1 — GWAS Catalog search API (live; release not exposed)