MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Myocardial infarction | 0.092 | 0.0319 | 0.00396 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.184 | 0.0654 | 0.00496 | Wald ratio | 1 | cis | NA |
| Intracranial volume | -1.46e+04 | 5.35e+03 | 0.00653 | Wald ratio | 1 | cis | NA |
| Fracture resulting from simple fall | -0.0484 | 0.0194 | 0.0126 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | 0.173 | 0.073 | 0.0176 | Wald ratio | 1 | cis | NA |
| Amygdala volume | 15.2 | 6.62 | 0.0214 | Wald ratio | 1 | cis | NA |
| Hirschsprung’s disease | 0.643 | 0.283 | 0.0228 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | 0.0939 | 0.0415 | 0.0237 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | 0.0649 | 0.0291 | 0.0258 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | 0.0612 | 0.0295 | 0.0383 | Wald ratio | 1 | cis | NA |
| Fasting glucose | -0.0434 | 0.0235 | 0.0643 | Wald ratio | 1 | cis | NA |
| Cough on most days | -0.0688 | 0.0387 | 0.0752 | Wald ratio | 1 | cis | NA |
| …and 72 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
29 association rows across 26 traits (20 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Gamma-interferon-inducible protein 16 levels (IFI16.12893.15 | 3e-49 | rs72709516 | 1 | GCST90241236 | no MR -> candidate analysis |
| DNA methylation-estimated granulocyte proportions | 5e-49 | rs856046 | 2 | GCST90014293 | no MR -> candidate analysis |
| SLAMF8 protein levels | 7e-48 | rs145587930 | 1 | GCST90470652 | no MR -> candidate analysis |
| Hematology traits | 5e-47 | rs4657616 | 1 | GCST001779 | no MR -> candidate analysis |
| White blood cell count | 2e-44 | rs4657616 | 1 | GCST008049 | no MR -> candidate analysis |
| C-reactive protein levels (UKB data field 30710) | 1e-24 | rs140853922 | 1 | GCST90468064 | no MR -> candidate analysis |
| C-reactive protein levels (MTAG) | 1e-19 | rs140853922 | 1 | GCST90179146 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 9e-14 | rs1633267 | 2 | GCST90838669 | no MR -> candidate analysis |
| C-C motif chemokine 14 levels | 1e-13 | rs1633256 | 2 | GCST90161535 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (cystatin c) | 1e-13 | rs3835724 | 1 | GCST90428448 | no MR -> candidate analysis |
| Lymphocyte percentage of white cells | 2e-12 | rs1633267 | 1 | GCST90002389 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (creatinine, cystatin c | 9e-11 | rs3835724 | 1 | GCST90428446 | no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
Top diseases by Open Targets association (of 630 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Anisometropia | 0.414 | — | common-variant locus | no MR -> candidate analysis |
| aging | 0.409 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.304 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.304 | — | common-variant locus | no MR -> candidate analysis |
| neutropenia | 0.16 | — | common-variant locus | no MR -> candidate analysis |
| Decreased total leukocyte count | 0.134 | — | common-variant locus | no MR -> candidate analysis |
Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.7e-12, LOEUF=0.909 — LoF-tolerant |
| GWAS Catalog | 37 unique SNPs / 74 rows |
| ClinVar | 151 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 630 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IFI16’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 151 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 29 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q16666 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163565/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IFI16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IFI16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IFI16%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IFI16 — GWAS Catalog search API (live; release not exposed)