MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Parkinson’s disease | 0.818 | 0.268 | 0.00227 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | -0.276 | 0.102 | 0.00712 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | 0.152 | 0.0615 | 0.0136 | Wald ratio | 1 | cis | NA |
| Squamous cell lung cancer | 0.362 | 0.17 | 0.0328 | Wald ratio | 1 | cis | NA |
| Lung cancer | 0.24 | 0.115 | 0.0371 | Wald ratio | 1 | cis | NA |
| Autism | 0.441 | 0.214 | 0.0389 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoarthritis | 0.0986 | 0.0487 | 0.0429 | Wald ratio | 1 | cis | NA |
| Lumbar spine bone mineral density | -0.118 | 0.0605 | 0.0513 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.113 | 0.0591 | 0.0555 | Wald ratio | 1 | cis | NA |
| Fasting insulin | 0.0861 | 0.0451 | 0.0563 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | 0.199 | 0.106 | 0.0593 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: psoriasis | 0.227 | 0.122 | 0.0634 | Wald ratio | 1 | cis | NA |
| …and 70 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
31 association rows across 20 traits (25 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating IFNLR1 levels | 1e-95 | rs573848533 | 6 | GCST90860236 | no MR -> candidate analysis |
| IFNLR1 protein levels | 3e-61 | rs12751091 | 2 | GCST90469518 | no MR -> candidate analysis |
| Circulating IL22RA1 levels | 1e-55 | rs10903042 | 1 | GCST90859872 | no MR -> candidate analysis |
| FUCA1 protein levels | 3e-52 | rs10903035 | 2 | GCST90469275 | no MR -> candidate analysis |
| Interferon lambda receptor 1 levels | 2e-36 | rs139958347 | 2 | GCST90248000 | no MR -> candidate analysis |
| Psoriasis or type 2 diabetes (trans-disease meta-analysis) | 2e-13 | rs78312791 | 1 | GCST011991 | no MR -> candidate analysis |
| Psoriasis | 9e-12 | rs7552167 | 3 | GCST005527 | MR: beta=0.227, p=0.0634 (cis) |
| Psoriasis or type 2 diabetes (trans-disease meta-analysis)(o | 3e-11 | rs4649201 | 1 | GCST011990 | no MR -> candidate analysis |
| Psoriasis vulgaris | 3e-11 | rs7552167 | 2 | GCST003268 | no MR -> candidate analysis |
| Inflammatory skin disease | 2e-9 | rs10794648 | 1 | GCST002740 | no MR -> candidate analysis |
| Executive inhibition (word interference time) | 8e-9 | rs56226824 | 1 | GCST90566353 | no MR -> candidate analysis |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn | 1e-8 | rs7552167 | 1 | GCST005537 | no MR -> candidate analysis |
| …and 8 more traits (see JSON) |
Top diseases by Open Targets association (of 280 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| psoriasis | 0.814 | — | common-variant locus | MR: beta=0.227, p=0.0634 (cis) |
| psoriasis vulgaris | 0.622 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.62 | — | common-variant locus | no MR -> candidate analysis |
| ankylosing spondylitis | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| ulcerative colitis | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| Crohn disease | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| sclerosing cholangitis | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| hyperpituitarism | 0.417 | — | common-variant locus | no MR -> candidate analysis |
| acute tonsillitis | 0.416 | — | common-variant locus | no MR -> candidate analysis |
| skin disorder | 0.394 | — | common-variant locus | no MR -> candidate analysis |
Of the 10 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (Interferon lambda receptor) |
| gnomAD constraint | pLI=0.00015, LOEUF=0.732 — LoF-tolerant |
| GWAS Catalog | 54 unique SNPs / 108 rows |
| ClinVar | 115 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 280 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IFNLR1’ and resolved to ‘Interferon lambda receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 115 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 20 traits by best p-value, aggregated from 31 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8IU57 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000185436/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3831284/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IFNLR1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IFNLR1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IFNLR1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IFNLR1 — GWAS Catalog search API (live; release not exposed)