MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R55 Syncope and collapse | 0.347 | 0.0951 | 2.62e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K43 Ventral hernia | 0.4 | 0.129 | 0.00193 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: enlarged prostate | 0.252 | 0.0842 | 0.00278 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: basal cell carcinoma | 0.287 | 0.0996 | 0.00397 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.2 | 0.0722 | 0.00562 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | -0.0554 | 0.0229 | 0.0157 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | 0.0286 | 0.012 | 0.0173 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.105 | 0.0466 | 0.0243 | Wald ratio | 1 | cis | NA |
| Potassium in urine | 0.0283 | 0.0128 | 0.0265 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | 0.187 | 0.0843 | 0.0266 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | 0.227 | 0.118 | 0.0551 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.216 | 0.114 | 0.0596 | Wald ratio | 1 | cis | NA |
| …and 76 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
27 association rows across 18 traits (24 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| IGDCC4 protein levels | 2e-270 | rs12441796 | 4 | GCST90469523 | no MR -> candidate analysis |
| Immunoglobulin superfamily DCC subclass member 4 levels | 3e-119 | rs35223184 | 2 | GCST90248005 | no MR -> candidate analysis |
| Mean corpuscular volume | 4e-101 | rs113968785 | 2 | GCST90056174 | no MR -> candidate analysis |
| Mean corpuscular hemoglobin | 2e-49 | rs113968785 | 2 | GCST90002390 | no MR -> candidate analysis |
| Red blood cell count | 2e-44 | rs113968785 | 2 | GCST90002403 | no MR -> candidate analysis |
| Serum levels of protein IGDCC4 | 6e-36 | rs143814405 | 1 | GCST90090826 | no MR -> candidate analysis |
| Immunoglobulin superfamily DCC subclass member 4 levels (IGD | 4e-27 | rs35223184 | 1 | GCST90241477 | no MR -> candidate analysis |
| Estimated bone mineral density | 1e-26 | rs35558920 | 1 | GCST90726625 | no MR -> candidate analysis |
| Heel bone mineral density | 3e-25 | rs28665840 | 1 | GCST006979 | MR: beta=-0.0167, p=0.303 (cis) |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) | 1e-22 | rs1550026 | 1 | GCST90468072 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 1e-22 | rs686134 | 1 | GCST90838663 | no MR -> candidate analysis |
| Height (baseline) | 1e-16 | rs12904090 | 1 | GCST90565843 | no MR -> candidate analysis |
| …and 6 more traits (see JSON) |
Top diseases by Open Targets association (of 72 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.839 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.606 | — | common-variant locus | no MR -> candidate analysis |
| scleritis | 0.463 | — | common-variant locus | no MR -> candidate analysis |
| crush injury | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.31 | — | common-variant locus | no MR -> candidate analysis |
| autism spectrum disorder | 0.31 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.19 | — | common-variant locus | no MR -> candidate analysis |
| hypothyroidism | 0.096 | — | common-variant locus | MR: beta=-0.0983, p=0.112 (cis) |
| response to xenobiotic stimulus | 0.063 | — | common-variant locus | no MR -> candidate analysis |
| acquired polycythemia vera | 0.045 | — | common-variant locus | no MR -> candidate analysis |
| schizophrenia | 0.032 | — | common-variant locus | MR: beta=-0.0462, p=0.447 (cis) |
| mathematical ability | 0.032 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=4.1e-14, LOEUF=0.751 — LoF-tolerant |
| GWAS Catalog | 50 unique SNPs / 100 rows |
| ClinVar | 260 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 72 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IGDCC4’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 260 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 18 of 18 traits by best p-value, aggregated from 27 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8TDY8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000103742/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IGDCC4 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IGDCC4 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IGDCC4%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IGDCC4 — GWAS Catalog search API (live; release not exposed)