Protein Dossier — IGFBP1 (Insulin-like growth factor-binding protein 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Triglycerides |
0.731 |
0.0217 |
6.50e-250 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: gout |
0.884 |
0.0548 |
1.38e-58 |
Wald ratio |
1 |
trans |
NA |
| Total cholesterol |
0.326 |
0.0229 |
6.67e-46 |
Wald ratio |
1 |
trans |
NA |
| Urate |
0.49 |
0.035 |
1.56e-44 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: high cholesterol |
0.398 |
0.0286 |
7.29e-44 |
Wald ratio |
1 |
trans |
NA |
| Alcohol intake frequency |
0.294 |
0.0233 |
1.26e-36 |
Wald ratio |
1 |
trans |
NA |
| Fasting glucose |
-0.204 |
0.0197 |
5.57e-25 |
Wald ratio |
1 |
trans |
NA |
| Crohn’s disease |
0.73 |
0.0767 |
1.74e-21 |
Wald ratio |
1 |
trans |
NA |
| Inflammatory bowel disease |
0.491 |
0.0635 |
1.03e-14 |
Wald ratio |
1 |
trans |
NA |
| Sodium in urine |
0.119 |
0.0155 |
2.00e-14 |
Wald ratio |
1 |
trans |
NA |
| Weight |
-0.103 |
0.0139 |
1.05e-13 |
Wald ratio |
1 |
trans |
NA |
| Serum creatinine (eGFRcrea) |
0.0433 |
0.00586 |
1.45e-13 |
Wald ratio |
1 |
trans |
NA |
| …and 135 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2771_35_2 |
IGFBP-1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
11 association rows across 8 traits (10 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Height |
2e-30 |
rs1496496 |
1 |
GCST90245848 |
MR: beta=-0.127, p=2.62e-11 (trans) |
| IGFBP3 protein levels |
5e-29 |
rs9658222 |
4 |
GCST90469529 |
no MR -> candidate analysis |
| Circulating IGFBP1 levels |
6e-26 |
rs2331390 |
1 |
GCST90859951 |
no MR -> candidate analysis |
| IGFBP1 protein levels |
7e-14 |
rs28705240 |
1 |
GCST90469527 |
no MR -> candidate analysis |
| Insulin-like growth factor-binding protein 1 levels |
1e-12 |
rs10577484 |
1 |
GCST90248010 |
no MR -> candidate analysis |
| Myocardial infarction |
3e-8 |
rs117054298 |
1 |
GCST90018877 |
no MR -> candidate analysis |
| Blood pressure (pleiotropy model 1 DBP adjusted for estimate |
4e-8 |
rs10282088 |
1 |
GCST90239828 |
no MR -> candidate analysis |
| Blood pressure (pleiotropy model 2 SBP adjusted for estimate |
1e-7 |
rs10282088 |
1 |
GCST90239829 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 708 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Abnormality of the skeletal system |
0.147 |
— |
common-variant locus |
no MR -> candidate analysis |
| cataract |
0.139 |
— |
common-variant locus |
MR: beta=0.165, p=0.0247 (trans) |
| Epidermal Inclusion Cyst |
0.117 |
— |
common-variant locus |
no MR -> candidate analysis |
| tenosynovitis |
0.117 |
— |
common-variant locus |
no MR -> candidate analysis |
| senile cataract |
0.11 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 5 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Insulin-like growth factor-binding protein 1) |
| gnomAD constraint |
pLI=1e-13, LOEUF=1.81 — LoF-tolerant |
| GWAS Catalog |
83 unique SNPs / 166 rows |
| ClinVar |
63 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 708 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IGFBP1’ and resolved to ‘Insulin-like growth factor-binding protein 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 63 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 8 of 8 traits by best p-value, aggregated from 11 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P08833 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000146678/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4178/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IGFBP1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IGFBP1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IGFBP1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IGFBP1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:08:19 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none