Protein Dossier — IGFBP7 (Insulin-like growth factor-binding protein 7)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Neo-extraversion |
0.726 |
0.255 |
0.00439 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin concentration |
0.0301 |
0.0113 |
0.00785 |
Wald ratio |
1 |
cis |
NA |
| Years of schooling |
0.0359 |
0.0138 |
0.00932 |
Wald ratio |
1 |
cis |
NA |
| Neo-neuroticism |
-0.805 |
0.317 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.02 |
0.00804 |
0.0128 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
-0.0163 |
0.00679 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
-0.0154 |
0.00644 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: prostate cancer |
0.181 |
0.0772 |
0.019 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.0141 |
0.00634 |
0.0266 |
Wald ratio |
1 |
cis |
NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis |
1.39 |
0.64 |
0.0296 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis |
0.0996 |
0.0461 |
0.0306 |
Wald ratio |
1 |
cis |
NA |
| Body fat |
-0.0386 |
0.0182 |
0.0339 |
Wald ratio |
1 |
cis |
NA |
| …and 84 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3320_49_2 |
IGFBP-7 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
84 association rows across 56 traits (63 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IGFBP7 levels |
3e-774 |
rs10866442 |
8 |
GCST90859983 |
no MR -> candidate analysis |
| IGFBP7 protein levels |
7e-237 |
rs11936912 |
12 |
GCST90469532 |
no MR -> candidate analysis |
| Insulin-like growth factor-binding protein 7 levels |
4e-155 |
rs6827768 |
6 |
GCST90248012 |
no MR -> candidate analysis |
| Height |
7e-76 |
rs11573106 |
1 |
GCST90245848 |
no MR -> candidate analysis |
| Serum levels of protein IGFBP7 |
6e-43 |
rs1718860 |
1 |
GCST90088312 |
no MR -> candidate analysis |
| Insulin-like growth factor-binding protein 7 levels (IGFBP7. |
5e-38 |
rs1718849 |
1 |
GCST90241520 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
1e-37 |
rs17087401 |
1 |
GCST90838671 |
no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia |
8e-32 |
rs2079916; rs13131244; rs17579638; rs17087693 |
2 |
GCST008413 |
no MR -> candidate analysis |
| Blood protein levels |
6e-28 |
rs1718860 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Circulating SFTPD levels |
5e-21 |
rs1614526 |
1 |
GCST90859954 |
no MR -> candidate analysis |
| Heel bone mineral density |
2e-18 |
rs11133474 |
2 |
GCST006433 |
MR: beta=0.0124, p=0.223 (cis) |
| SPINK2 protein levels |
5e-16 |
rs116579804 |
3 |
GCST90470722 |
no MR -> candidate analysis |
| …and 44 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 567 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| familial retinal arterial macroaneurysm |
0.694 |
— |
established (curated) |
no MR -> candidate analysis |
| alcohol drinking |
0.523 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial fibrillation |
0.47 |
— |
common-variant locus |
no MR -> candidate analysis |
| schizophrenia |
0.475 |
— |
common-variant locus |
no MR -> candidate analysis |
| protozoa infectious disease |
0.479 |
— |
common-variant locus |
no MR -> candidate analysis |
| degeneration of macula and posterior pole |
0.463 |
— |
common-variant locus |
no MR -> candidate analysis |
| refractive error |
0.46 |
— |
common-variant locus |
no MR -> candidate analysis |
| hyperemesis gravidarum |
0.441 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.425 |
— |
common-variant locus |
no MR -> candidate analysis |
| head and neck cancer |
0.437 |
— |
common-variant locus |
no MR -> candidate analysis |
| anemia (phenotype) |
0.437 |
— |
common-variant locus |
no MR -> candidate analysis |
| cardiac arrest |
0.422 |
— |
common-variant locus |
no MR -> candidate analysis |
| pituitary gland disorder |
0.425 |
— |
common-variant locus |
no MR -> candidate analysis |
| seasonal allergic rhinitis |
0.422 |
— |
common-variant locus |
no MR -> candidate analysis |
| stroke disorder |
0.405 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.1e-11, LOEUF=1.42 — LoF-tolerant |
| GWAS Catalog |
106 unique SNPs / 222 rows |
| ClinVar |
81 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 567 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IGFBP7’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 81 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 56 traits by best p-value, aggregated from 84 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q16270 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163453/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IGFBP7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IGFBP7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IGFBP7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IGFBP7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:09:07 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none