Protein Dossier — IL10RB (Interleukin-10 receptor subunit beta)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: retinal detachment |
0.613 |
0.17 |
3.04e-04 |
Wald ratio |
1 |
cis |
NA |
| Urate |
0.119 |
0.0419 |
0.00457 |
Wald ratio |
1 |
cis |
NA |
| Mean cell volume |
0.575 |
0.228 |
0.0115 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.431 |
0.173 |
0.0128 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
-0.0754 |
0.0307 |
0.0139 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.102 |
0.044 |
0.0201 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
94.3 |
44.1 |
0.0326 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
-0.51 |
0.241 |
0.0342 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.142 |
0.0675 |
0.0354 |
Wald ratio |
1 |
cis |
NA |
| Ovarian cancer |
-0.229 |
0.112 |
0.0416 |
Wald ratio |
1 |
cis |
NA |
| High grade serous ovarian cancer |
-0.265 |
0.133 |
0.0474 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
-0.0292 |
0.015 |
0.0515 |
Wald ratio |
1 |
cis |
NA |
| …and 80 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2631_50_2 |
IL-10 Rb |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
88 association rows across 45 traits (80 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| BTN2A1/IL10RB protein level ratio |
3e-2884 |
rs765429 |
1 |
GCST90313544 |
no MR -> candidate analysis |
| IFNGR1/IL10RB protein level ratio |
8e-2593 |
rs765429 |
1 |
GCST90315127 |
no MR -> candidate analysis |
| Circulating IL10RB levels |
3e-2001 |
rs2266590 |
2 |
GCST90859871 |
no MR -> candidate analysis |
| HYOU1/IL10RB protein level ratio |
6e-1956 |
rs765429 |
1 |
GCST90315101 |
no MR -> candidate analysis |
| CSF1/IL10RB protein level ratio |
4e-1932 |
rs765429 |
1 |
GCST90314284 |
no MR -> candidate analysis |
| B4GALT1/IL10RB protein level ratio |
2e-1735 |
rs765429 |
1 |
GCST90313431 |
no MR -> candidate analysis |
| CD58/IL10RB protein level ratio |
2e-1672 |
rs765429 |
1 |
GCST90313850 |
no MR -> candidate analysis |
| Interleukin-10 receptor subunit beta levels |
4e-316 |
rs2266590 |
5 |
GCST90274797 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein IL10RB levels |
7e-138 |
rs2843717 |
1 |
GCST90944362 |
no MR -> candidate analysis |
| IFNAR1 protein levels |
9e-85 |
rs62654645 |
5 |
GCST90469512 |
no MR -> candidate analysis |
| IL10RB protein levels |
1e-77 |
rs370410755 |
10 |
GCST90469545 |
no MR -> candidate analysis |
| IFNGR2 protein levels |
1e-57 |
rs193235943 |
4 |
GCST90469514 |
no MR -> candidate analysis |
| …and 33 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 483 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| inflammatory bowel disease 25 |
0.915 |
— |
established (curated) |
no MR -> candidate analysis |
| Autosomal recessive early-onset inflammatory bowel disease |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| IL10-related early-onset inflammatory bowel disease |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| COVID-19 |
0.755 |
— |
common-variant locus |
no MR -> candidate analysis |
| obesity disorder |
0.389 |
— |
common-variant locus |
no MR -> candidate analysis |
| major depressive disorder |
0.34 |
— |
common-variant locus |
MR: beta=0.13, p=0.41 (cis) |
| hereditary disease |
0.314 |
— |
established (curated) |
no MR -> candidate analysis |
| osteoarthritis |
0.277 |
— |
common-variant locus |
MR: beta=0.0627, p=0.252 (cis) |
| respiratory failure |
0.261 |
— |
common-variant locus |
no MR -> candidate analysis |
| systemic lupus erythematosus |
0.241 |
— |
common-variant locus |
MR: beta=-0.35, p=0.291 (cis) |
| age-related macular degeneration |
0.166 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 11 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (IL22 Receptor) |
| gnomAD constraint |
pLI=1.2e-08, LOEUF=1.05 — LoF-tolerant |
| GWAS Catalog |
101 unique SNPs / 212 rows |
| ClinVar |
361 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 483 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL10RB’ and resolved to ‘IL22 Receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 361 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 45 traits by best p-value, aggregated from 88 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q08334 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000243646/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4804251/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL10RB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL10RB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL10RB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL10RB — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:09:54 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none