Protein Dossier — IL11RA (Interleukin-11 receptor subunit alpha)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypertension |
-0.057 |
0.0172 |
9.42e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pneumothorax |
0.735 |
0.24 |
0.00221 |
Wald ratio |
1 |
cis |
NA |
| Cigarettes smoked per day |
-1.71 |
0.597 |
0.00424 |
Wald ratio |
1 |
cis |
NA |
| Multiple sclerosis |
-0.192 |
0.0703 |
0.00638 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
0.142 |
0.0526 |
0.00705 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.28 |
0.11 |
0.0105 |
Wald ratio |
1 |
cis |
NA |
| PGC cross-disorder traits |
0.126 |
0.0494 |
0.0106 |
Wald ratio |
1 |
cis |
NA |
| Cough on most days |
-0.137 |
0.0559 |
0.0145 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.0226 |
0.00954 |
0.0177 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: anxiety or panic attacks |
0.165 |
0.0701 |
0.0184 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Arm |
0.187 |
0.0803 |
0.0202 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0191 |
0.00826 |
0.0209 |
Wald ratio |
1 |
cis |
NA |
| …and 111 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3814_63_1 |
IL-11 RA |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
9 association rows across 8 traits (8 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Interleukin-11 receptor subunit alpha levels |
6e-99 |
rs11575578 |
1 |
GCST90248029 |
no MR -> candidate analysis |
| Interleukin-11 receptor subunit alpha levels (IL11RA.3814.63 |
4e-26 |
rs11575578 |
1 |
GCST90241586 |
no MR -> candidate analysis |
| C-C motif chemokine 27 levels |
5e-22 |
rs2812357 |
1 |
GCST90059913 |
no MR -> candidate analysis |
| Height |
9e-14 |
rs11575580 |
2 |
GCST007841 |
MR: beta=-0.0188, p=0.241 (cis) |
| Circulating MEPE levels |
9e-13 |
rs11575580 |
1 |
GCST90859653 |
no MR -> candidate analysis |
| MEPE protein levels |
1e-12 |
rs11575580 |
1 |
GCST90469889 |
no MR -> candidate analysis |
| Body shape phenotype PC2 |
3e-11 |
rs11575580 |
1 |
GCST90832990 |
no MR -> candidate analysis |
| Height (baseline) |
5e-9 |
rs11575580 |
1 |
GCST90565843 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 200 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| craniosynostosis and dental anomalies |
0.843 |
— |
established (curated) |
no MR -> candidate analysis |
| craniosynostosis |
0.596 |
— |
established (curated) |
no MR -> candidate analysis |
| protozoa infectious disease |
0.293 |
— |
common-variant locus |
no MR -> candidate analysis |
| asthma |
0.112 |
— |
common-variant locus |
MR: beta=-0.0435, p=0.12 (cis) |
Of the 4 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Interleukin-11 receptor subunit alpha) |
| gnomAD constraint |
pLI=4.5e-16, LOEUF=1.13 — LoF-tolerant |
| GWAS Catalog |
63 unique SNPs / 126 rows |
| ClinVar |
215 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 200 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL11RA’ and resolved to ‘Interleukin-11 receptor subunit alpha’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 215 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 8 of 8 traits by best p-value, aggregated from 9 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q14626 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000137070/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2050/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL11RA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL11RA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL11RA%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL11RA — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:10:10 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none