Protein Dossier — IL15RA (Interleukin-15 receptor subunit alpha)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.0697 |
0.0208 |
8.16e-04 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.0181 |
0.00609 |
0.003 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
0.00968 |
0.00392 |
0.0135 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
0.0774 |
0.0324 |
0.0168 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
0.0116 |
0.00502 |
0.0205 |
Wald ratio |
1 |
cis |
NA |
| Weight |
0.00991 |
0.00443 |
0.0254 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
28.7 |
13 |
0.027 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
0.0717 |
0.0334 |
0.0318 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.0159 |
0.00742 |
0.0326 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.137 |
0.0644 |
0.0333 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
-0.0581 |
0.0292 |
0.0468 |
Wald ratio |
1 |
cis |
NA |
| Mean cell volume |
-0.108 |
0.0546 |
0.0479 |
Wald ratio |
1 |
cis |
NA |
| …and 91 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3445_53_2 |
IL-15 Ra |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
115 association rows across 60 traits (104 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| IL2RA/NCR1 protein level ratio |
7e-902 |
rs7911500 |
1 |
GCST90315161 |
no MR -> candidate analysis |
| Circulating IL15RA levels |
2e-543 |
rs2228059 |
9 |
GCST90859870 |
no MR -> candidate analysis |
| IL15RA protein levels |
8e-276 |
rs3136630 |
9 |
GCST90469555 |
no MR -> candidate analysis |
| Interleukin-15 receptor subunit alpha levels |
2e-184 |
rs2228059 |
8 |
GCST90274800 |
no MR -> candidate analysis |
| Soluble interleukin-2 receptor subunit alpha |
1e-100 |
rs7911500 |
2 |
GCST003088 |
no MR -> candidate analysis |
| Interleukin-15 receptor subunit alpha levels (IL15RA.14054.1 |
2e-91 |
rs8177641 |
4 |
GCST90241594 |
no MR -> candidate analysis |
| IL2RA protein levels |
7e-73 |
rs146712466 |
7 |
GCST90469585 |
no MR -> candidate analysis |
| Circulating IL2RA levels |
4e-66 |
rs183050850 |
2 |
GCST90859919 |
no MR -> candidate analysis |
| Serum levels of protein IL15RA |
1e-63 |
rs7086174 |
5 |
GCST90087746 |
no MR -> candidate analysis |
| Interleukin-15 receptor subunit alpha (analyte X14054.17) le |
3e-61 |
rs7086174 |
1 |
GCST90422434 |
no MR -> candidate analysis |
| Circulating NCR1 levels (id: OID01007_OID20566) |
1e-44 |
rs8177653 |
3 |
GCST90860233 |
no MR -> candidate analysis |
| Circulating NCR1 levels (id: OID00816_OID20566) |
1e-43 |
rs8177653 |
3 |
GCST90860146 |
no MR -> candidate analysis |
| …and 48 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 312 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| neuroblastoma |
0.55 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.463 |
— |
common-variant locus |
no MR -> candidate analysis |
| arthropathy |
0.457 |
— |
common-variant locus |
no MR -> candidate analysis |
| atopic eczema |
0.123 |
— |
common-variant locus |
no MR -> candidate analysis |
| rheumatoid arthritis |
0.031 |
— |
common-variant locus |
MR: beta=-0.0581, p=0.0468 (cis) |
| Iron deficiency anemia |
0.111 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 6 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (IL15-IL15 receptor) |
| gnomAD constraint |
pLI=4.5e-10, LOEUF=1.49 — LoF-tolerant |
| GWAS Catalog |
160 unique SNPs / 403 rows |
| ClinVar |
99 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 312 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL15RA’ and resolved to ‘IL15-IL15 receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 99 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 60 traits by best p-value, aggregated from 115 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q13261 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000134470/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4106128/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL15RA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL15RA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL15RA%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL15RA — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:11:28 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none