Protein Dossier — IL16 (Pro-interleukin-16)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Height |
-0.0353 |
0.00808 |
1.28e-05 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: small intestine or small bowel cancer |
0.539 |
0.174 |
0.00192 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.104 |
0.0354 |
0.00331 |
Wald ratio |
1 |
cis |
NA |
| 2hr glucose |
0.135 |
0.0529 |
0.0106 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.139 |
0.0554 |
0.0123 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
0.0992 |
0.0446 |
0.0261 |
Wald ratio |
1 |
cis |
NA |
| HbA1C |
0.0207 |
0.00955 |
0.0301 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
0.0536 |
0.0251 |
0.0326 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.161 |
0.0782 |
0.0398 |
Wald ratio |
1 |
cis |
NA |
| Fractured or broken bones in last 5 years |
0.0375 |
0.0183 |
0.0404 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: H25 Senile cataract |
0.124 |
0.0615 |
0.0435 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
-0.247 |
0.127 |
0.0517 |
Wald ratio |
1 |
cis |
NA |
| …and 95 more outcomes (see JSON) |
|
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|
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2774_10_3 |
IL-16 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
68 association rows across 36 traits (64 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL16 levels |
2e-2545 |
rs4778639 |
4 |
GCST90859794 |
no MR -> candidate analysis |
| IL16/LSP1 protein level ratio |
3e-1951 |
rs4778639 |
1 |
GCST90315151 |
no MR -> candidate analysis |
| CD5/IL16 protein level ratio |
2e-1684 |
rs4577037 |
1 |
GCST90313861 |
no MR -> candidate analysis |
| Pro-interleukin-16 levels |
4e-970 |
rs4778639 |
3 |
GCST90012049 |
no MR -> candidate analysis |
| Interleukin-16 levels |
3e-560 |
rs58754882 |
9 |
GCST90248036 |
no MR -> candidate analysis |
| Serum levels of protein IL16 |
2e-147 |
rs4778639 |
1 |
GCST90088064 |
no MR -> candidate analysis |
| StAR-related lipid transfer protein 5 levels |
1e-95 |
rs58076056 |
1 |
GCST90249673 |
no MR -> candidate analysis |
| Blood protein levels |
7e-83 |
rs7166271 |
2 |
GCST006585 |
no MR -> candidate analysis |
| IL16 protein levels |
2e-75 |
rs11632978 |
4 |
GCST90469557 |
no MR -> candidate analysis |
| Hair color |
3e-73 |
rs7179134 |
1 |
GCST007082 |
no MR -> candidate analysis |
| Height |
1e-70 |
rs4778639 |
10 |
GCST90245848 |
MR: beta=-0.0353, p=1.28e-05 (cis) |
| Blood protein levels in cardiovascular risk |
3e-62 |
rs139879640 |
1 |
GCST009731 |
no MR -> candidate analysis |
| …and 24 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 571 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hair color |
0.559 |
— |
common-variant locus |
no MR -> candidate analysis |
| placenta praevia |
0.532 |
— |
common-variant locus |
no MR -> candidate analysis |
| primary biliary cholangitis |
0.513 |
— |
common-variant locus |
no MR -> candidate analysis |
| nodular goiter |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| peritonitis |
0.371 |
— |
common-variant locus |
no MR -> candidate analysis |
| urolithiasis |
0.324 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.324 |
— |
common-variant locus |
no MR -> candidate analysis |
| facial morphology |
0.324 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary artery disorder |
0.057 |
— |
common-variant locus |
no MR -> candidate analysis |
| tuberculosis |
0.052 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 10 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=7.4e-13, LOEUF=0.746 — LoF-tolerant |
| GWAS Catalog |
62 unique SNPs / 118 rows |
| ClinVar |
270 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 571 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL16’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 270 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 36 traits by best p-value, aggregated from 68 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q14005 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000172349/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL16%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=IL16 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/IL16 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:11:39 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none