Protein Dossier — IL17RA (Interleukin-17 receptor A)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Cancer code self-reported: small intestine or small bowel cancer |
0.279 |
0.107 |
0.00932 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0092 |
0.00384 |
0.0166 |
Wald ratio |
1 |
cis |
NA |
| Sodium in urine |
0.00671 |
0.00292 |
0.0213 |
Wald ratio |
1 |
cis |
NA |
| Autism |
-0.0747 |
0.0358 |
0.037 |
Wald ratio |
1 |
cis |
NA |
| Haemoglobin concentration |
0.0366 |
0.0181 |
0.0425 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
-0.0426 |
0.0221 |
0.0535 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.054 |
0.0293 |
0.0654 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
-0.0212 |
0.0116 |
0.0665 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee |
-0.036 |
0.0207 |
0.0813 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
0.0615 |
0.0366 |
0.0928 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal |
-0.0425 |
0.0261 |
0.104 |
Wald ratio |
1 |
cis |
NA |
| Pallidum volume |
3.76 |
2.37 |
0.112 |
Wald ratio |
1 |
cis |
NA |
| …and 83 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2992_59_2 |
IL-17 sR |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
133 association rows across 43 traits (132 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL17RA levels |
4e-5490 |
rs4819959 |
9 |
GCST90859915 |
no MR -> candidate analysis |
| Interleukin-17 receptor A levels |
8e-1169 |
rs4819959 |
13 |
GCST90248041 |
no MR -> candidate analysis |
| Interleukin-17 receptor A levels (IL17RA.2992.59.2) |
6e-483 |
rs397780227 |
3 |
GCST90241597 |
no MR -> candidate analysis |
| Monocyte count |
3e-465 |
rs140221307 |
15 |
GCST90025950 |
no MR -> candidate analysis |
| Monocyte percentage of white cells |
1e-370 |
rs140221307 |
6 |
GCST90002394 |
no MR -> candidate analysis |
| Blood protein levels |
8e-347 |
rs2241047 |
1 |
GCST006585 |
no MR -> candidate analysis |
| monocyte (absolute count, mean, inv-norm transformed) |
1e-323 |
rs140221307 |
2 |
GCST90475502 |
no MR -> candidate analysis |
| monocyte (fraction, mean, inv-norm transformed) |
1e-323 |
rs140221307 |
2 |
GCST90475511 |
no MR -> candidate analysis |
| monocyte (absolute count, minimum, inv-norm transformed) |
3e-211 |
rs140221307 |
2 |
GCST90475505 |
no MR -> candidate analysis |
| monocyte (fraction, maximum, inv-norm transformed) |
2e-203 |
rs140221307 |
2 |
GCST90475508 |
no MR -> candidate analysis |
| monocyte (fraction, minimum, inv-norm transformed) |
1e-187 |
rs140221307 |
2 |
GCST90475514 |
no MR -> candidate analysis |
| monocyte (absolute count, maximum, inv-norm transformed) |
4e-175 |
rs140221307 |
2 |
GCST90475499 |
no MR -> candidate analysis |
| …and 31 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 789 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| immunodeficiency 51 |
0.844 |
— |
established (curated) |
no MR -> candidate analysis |
| psoriasis |
0.398 |
— |
established (curated) |
MR: beta=-0.0258, p=0.368 (cis) |
| Chronic mucocutaneous candidosis |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| chronic mucocutaneous candidiasis |
0.574 |
— |
established (curated) |
no MR -> candidate analysis |
| polycythemia |
0.214 |
— |
common-variant locus |
no MR -> candidate analysis |
| enteritis |
0.207 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 6 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Interleukin-17 receptor A) |
| gnomAD constraint |
pLI=3.3e-08, LOEUF=0.898 — LoF-tolerant |
| GWAS Catalog |
112 unique SNPs / 244 rows |
| ClinVar |
1113 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 789 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL17RA’ and resolved to ‘Interleukin-17 receptor A’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 1113 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 43 traits by best p-value, aggregated from 133 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q96F46 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000177663/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3580485/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL17RA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL17RA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL17RA%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=IL17RA — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/IL17RA — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:11:57 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none