Protein Dossier — IL17RB (Interleukin-17 receptor B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Height |
0.0398 |
0.0144 |
0.0057 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0205 |
0.00765 |
0.00732 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: ankylosing spondylitis |
0.225 |
0.09 |
0.0126 |
Wald ratio |
1 |
cis |
NA |
| Fracture resulting from simple fall |
0.0348 |
0.0152 |
0.022 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bone disorder |
0.225 |
0.102 |
0.0272 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
0.0129 |
0.006 |
0.0313 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Ankle |
-0.123 |
0.0572 |
0.032 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R55 Syncope and collapse |
-0.158 |
0.0738 |
0.032 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
-0.134 |
0.0641 |
0.037 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee |
0.0763 |
0.0368 |
0.0382 |
Wald ratio |
1 |
cis |
NA |
| Amyotrophic lateral sclerosis |
0.0959 |
0.048 |
0.0457 |
Wald ratio |
1 |
cis |
NA |
| Creatinine (enzymatic) in urine |
0.0113 |
0.00565 |
0.0464 |
Wald ratio |
1 |
cis |
NA |
| …and 60 more outcomes (see JSON) |
|
|
|
|
|
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5084_154_3 |
IL-17B R |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
11 association rows across 8 traits (9 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL17RB levels |
7e-1353 |
rs2232346 |
4 |
GCST90860571 |
no MR -> candidate analysis |
| IL17RB protein levels |
2e-148 |
rs142978915 |
1 |
GCST90469563 |
no MR -> candidate analysis |
| Interleukin-17 receptor B levels (IL17RB.5084.154.3) |
4e-77 |
rs2232346 |
1 |
GCST90241598 |
no MR -> candidate analysis |
| Interleukin-17 receptor B (analyte X5084.154) levels |
4e-50 |
rs2232346 |
1 |
GCST90426230 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein IL17RB levels |
2e-22 |
rs2232346 |
1 |
GCST90943508 |
no MR -> candidate analysis |
| Height |
8e-10 |
rs12637033 |
1 |
GCST90245848 |
MR: beta=0.0398, p=0.0057 (cis) |
| Vesicoureteral reflux |
2e-7 |
rs55754695 |
1 |
GCST012183 |
no MR -> candidate analysis |
| N-methylpipecolate levels in elite athletes |
2e-6 |
rs1043261 |
1 |
GCST90134229 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 256 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| injury |
0.47 |
— |
common-variant locus |
MR: beta=0.136, p=0.303 (cis) |
| hypertensive disorder |
0.326 |
— |
common-variant locus |
no MR -> candidate analysis |
| response to xenobiotic stimulus |
0.256 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.191 |
— |
common-variant locus |
no MR -> candidate analysis |
| cardiovascular disorder |
0.181 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.174 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.165 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian neoplasm |
0.154 |
— |
common-variant locus |
no MR -> candidate analysis |
| urolithiasis |
0.134 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.134 |
— |
common-variant locus |
no MR -> candidate analysis |
| mathematical ability |
0.132 |
— |
common-variant locus |
no MR -> candidate analysis |
| Increased blood pressure |
0.108 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental abruption |
0.103 |
— |
common-variant locus |
no MR -> candidate analysis |
| substance-related disorder |
0.095 |
— |
common-variant locus |
no MR -> candidate analysis |
| obesity disorder |
0.088 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=9.2e-11, LOEUF=1.08 — LoF-tolerant |
| GWAS Catalog |
88 unique SNPs / 173 rows |
| ClinVar |
98 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 256 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL17RB’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 98 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 8 of 8 traits by best p-value, aggregated from 11 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9NRM6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000056736/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL17RB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL17RB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL17RB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL17RB — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:12:11 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none