Protein Dossier — IL17RD (Interleukin-17 receptor D)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Forced expiratory volume in 1-second (FEV1) |
0.0218 |
0.00494 |
1.04e-05 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0308 |
0.00739 |
3.06e-05 |
Wald ratio |
1 |
cis |
NA |
| Major depressive disorder |
-0.19 |
0.0502 |
1.48e-04 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.0176 |
0.00469 |
1.69e-04 |
Wald ratio |
1 |
cis |
NA |
| Bipolar disorder |
-0.183 |
0.0565 |
0.00121 |
Wald ratio |
1 |
cis |
NA |
| HOMA-B |
-0.0216 |
0.008 |
0.00688 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.461 |
0.178 |
0.00952 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
0.094 |
0.0362 |
0.00952 |
Wald ratio |
1 |
cis |
NA |
| Packed cell volume |
-0.114 |
0.0454 |
0.0123 |
Wald ratio |
1 |
cis |
NA |
| Haemoglobin concentration |
-0.0374 |
0.0151 |
0.0135 |
Wald ratio |
1 |
cis |
NA |
| Autism |
0.163 |
0.0666 |
0.0147 |
Wald ratio |
1 |
cis |
NA |
| Red blood cell count |
-0.0138 |
0.00584 |
0.0178 |
Wald ratio |
1 |
cis |
NA |
| …and 108 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3376_49_2 |
IL-17 RD |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
48 association rows across 30 traits (46 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Interleukin-17 receptor D levels |
8e-422 |
rs76645245 |
7 |
GCST90248043 |
no MR -> candidate analysis |
| Interleukin-17 receptor D levels (IL17RD.3376.49.2) |
3e-74 |
rs6776722 |
2 |
GCST90241600 |
no MR -> candidate analysis |
| Serum levels of protein IL17RD |
4e-74 |
rs2035656 |
2 |
GCST90088350 |
no MR -> candidate analysis |
| Mean platelet thrombocyte volume (UKB data field 30100) |
3e-57 |
rs73082974 |
2 |
GCST90468087 |
no MR -> candidate analysis |
| Height |
6e-38 |
rs17216893 |
9 |
GCST90245848 |
MR: beta=0.0125, p=0.088 (cis) |
| Blood protein levels |
9e-37 |
rs59527464 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Interleukin-17 receptor D level in Chronic kidney disease wi |
1e-21 |
rs6780995 |
1 |
GCST90237348 |
no MR -> candidate analysis |
| Prostaglandin-H2 D-isomerase protein levels (SomaScan ID:337 |
4e-18 |
rs11916303 |
1 |
GCST90442822 |
no MR -> candidate analysis |
| Cortical surface area |
2e-16 |
rs17235841 |
1 |
GCST90091060 |
no MR -> candidate analysis |
| Physical function (baseline) |
9e-16 |
rs56164953 |
2 |
GCST90565837 |
no MR -> candidate analysis |
| Vertex-wise cortical surface area |
2e-15 |
rs17235841 |
1 |
GCST90095130 |
no MR -> candidate analysis |
| FEV1 |
2e-13 |
rs12494525 |
1 |
GCST90270081 |
MR: beta=0.0218, p=1.04e-05 (cis) |
| …and 18 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 332 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Kallmann syndrome |
0.853 |
— |
established (curated) |
no MR -> candidate analysis |
| hypogonadotropic hypogonadism 18 with or without anosmia |
0.587 |
— |
established (curated) |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.624 |
— |
common-variant locus |
no MR -> candidate analysis |
| Delayed puberty |
0.596 |
— |
established (curated) |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.483 |
— |
common-variant locus |
no MR -> candidate analysis |
| Cerebral arteriovenous malformation |
0.486 |
— |
established (curated) |
no MR -> candidate analysis |
| asthma |
0.483 |
— |
common-variant locus |
MR: beta=-0.0222, p=0.175 (cis) |
| placenta praevia |
0.235 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypogonadotropic hypogonadism |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| hypogonadism |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 10 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=2.9e-11, LOEUF=0.813 — LoF-tolerant |
| GWAS Catalog |
56 unique SNPs / 112 rows |
| ClinVar |
330 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 332 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL17RD’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 330 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 48 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q8NFM7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000144730/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL17RD — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL17RD — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL17RD%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL17RD — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:12:23 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none