Protein Dossier — IL18RAP (Interleukin-18 receptor accessory protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb |
0.119 |
0.0363 |
0.00105 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries |
0.156 |
0.0544 |
0.0042 |
Wald ratio |
1 |
cis |
NA |
| Urate |
0.0309 |
0.0119 |
0.0097 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
-0.249 |
0.101 |
0.0139 |
Wald ratio |
1 |
cis |
NA |
| Chronic kidney disease |
0.0803 |
0.033 |
0.0148 |
Wald ratio |
1 |
cis |
NA |
| Percent emphysema |
0.0513 |
0.0229 |
0.0249 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
0.05 |
0.0224 |
0.0255 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
-0.0508 |
0.0232 |
0.0288 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
-0.109 |
0.0499 |
0.029 |
Wald ratio |
1 |
cis |
NA |
| Serum creatinine (eGFRcrea) |
-0.00412 |
0.0019 |
0.0297 |
Wald ratio |
1 |
cis |
NA |
| Childhood intelligence |
-0.0626 |
0.0288 |
0.0299 |
Wald ratio |
1 |
cis |
NA |
| Platelet count |
1.82 |
0.887 |
0.0406 |
Wald ratio |
1 |
cis |
NA |
| …and 96 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2993_1_2 |
IL-18 Rb |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
83 association rows across 47 traits (78 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Interleukin-18 receptor 1 levels (IL18R1.3446.7.2) |
1e-273 |
rs1420106 |
1 |
GCST90241607 |
no MR -> candidate analysis |
| IL1RL1 protein levels |
7e-218 |
rs115725744 |
4 |
GCST90469574 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
3e-213 |
rs4479442 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| interleukin-18 receptor 1 levels |
1e-133 |
rs1807782 |
1 |
GCST90161790 |
no MR -> candidate analysis |
| Atopic dermatitis |
2e-100 |
rs2272128 |
9 |
GCST90244787 |
no MR -> candidate analysis |
| Interleukin-1 receptor-like 1 levels |
7e-98 |
rs397868590 |
3 |
GCST90248051 |
no MR -> candidate analysis |
| IL18R1 protein levels |
5e-50 |
rs181156130 |
9 |
GCST90469565 |
no MR -> candidate analysis |
| Interleukin-18 receptor accessory protein levels |
1e-40 |
rs6748390 |
3 |
GCST90137708 |
no MR -> candidate analysis |
| Asthma or irritable bowel syndrome (MTAG) |
2e-37 |
rs3755265 |
1 |
GCST90570612 |
no MR -> candidate analysis |
| ST2 levels |
9e-36 |
rs11465729 |
1 |
GCST90274911 |
no MR -> candidate analysis |
| Lymphocyte count |
4e-32 |
rs6755786 |
6 |
GCST90002316 |
no MR -> candidate analysis |
| Eosinophil count |
5e-32 |
rs34020101 |
2 |
GCST004606 |
no MR -> candidate analysis |
| …and 35 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 525 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| asthma |
0.766 |
— |
common-variant locus |
no MR -> candidate analysis |
| atopic eczema |
0.71 |
— |
common-variant locus |
no MR -> candidate analysis |
| inflammatory bowel disease |
0.679 |
— |
common-variant locus |
MR: beta=0.0269, p=0.237 (cis) |
| Ascending aortic dissection |
0.684 |
— |
established (curated) |
no MR -> candidate analysis |
| Crohn disease |
0.668 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic rhinosinusitis |
0.629 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.545 |
— |
common-variant locus |
MR: beta=0.0386, p=0.176 (cis) |
| Eczematoid dermatitis |
0.529 |
— |
common-variant locus |
no MR -> candidate analysis |
| skin disorder |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| celiac disease |
0.476 |
— |
common-variant locus |
no MR -> candidate analysis |
| dermatitis |
0.457 |
— |
common-variant locus |
no MR -> candidate analysis |
| lichen planus |
0.415 |
— |
common-variant locus |
no MR -> candidate analysis |
| seborrheic keratosis |
0.409 |
— |
common-variant locus |
no MR -> candidate analysis |
| allergic rhinitis |
0.364 |
— |
common-variant locus |
MR: beta=-0.0508, p=0.0288 (cis) |
| atopic conjunctivitis |
0.334 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (IL18 Receptor) |
| gnomAD constraint |
pLI=3.9e-08, LOEUF=0.838 — LoF-tolerant |
| GWAS Catalog |
159 unique SNPs / 456 rows |
| ClinVar |
104 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 525 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL18RAP’ and resolved to ‘IL18 Receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 104 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 47 traits by best p-value, aggregated from 83 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O95256 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000115607/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4804253/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL18RAP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL18RAP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL18RAP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL18RAP — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:13:19 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none