MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Ulcerative colitis | 0.196 | 0.0319 | 7.61e-10 | Wald ratio | 1 | cis | 0.00971 |
| Inflammatory bowel disease | 0.153 | 0.0252 | 1.37e-09 | Wald ratio | 1 | cis | 2.46e-09 |
| Non-cancer illness code self-reported: asthma | -0.0756 | 0.0185 | 4.20e-05 | Wald ratio | 1 | cis | NA |
| Crohn’s disease | 0.12 | 0.0306 | 8.61e-05 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0171 | 0.00501 | 6.31e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.137 | 0.0405 | 6.97e-04 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.0196 | 0.0061 | 0.00131 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | 0.0879 | 0.0303 | 0.00374 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.188 | 0.0663 | 0.00464 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0281 | 0.0101 | 0.00542 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | -0.0524 | 0.019 | 0.00576 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | 0.0199 | 0.00745 | 0.00766 | Wald ratio | 1 | cis | NA |
| …and 111 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
53 association rows across 30 traits (44 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating IL1R2 levels | 1e-2261 | rs2310170 | 3 | GCST90859972 | no MR -> candidate analysis |
| Interleukin-1 receptor type 2 levels | 5e-255 | rs2310170 | 6 | GCST90248054 | no MR -> candidate analysis |
| IL1R2 protein levels | 3e-220 | rs554778901 | 10 | GCST90469572 | no MR -> candidate analysis |
| Circulating IL1R1 levels | 2e-144 | rs10185424 | 2 | GCST90859959 | no MR -> candidate analysis |
| IL1R1 protein levels | 3e-111 | rs4851533 | 1 | GCST90469571 | no MR -> candidate analysis |
| Serum levels of protein IL1R2 | 1e-104 | rs7561191 | 1 | GCST90087809 | no MR -> candidate analysis |
| Interleukin-1 receptor type 1 levels | 9e-64 | rs7587167 | 1 | GCST90425563 | no MR -> candidate analysis |
| Interleukin-1 receptor type 2 levels (IL1R2.14133.93.3) | 6e-62 | rs7561460 | 1 | GCST90241579 | no MR -> candidate analysis |
| Blood protein levels | 7e-55 | rs7561460 | 1 | GCST006585 | no MR -> candidate analysis |
| IL1RL2 protein levels | 2e-45 | rs719250 | 2 | GCST90469575 | no MR -> candidate analysis |
| IL1RL1 protein levels | 8e-44 | rs4141134 | 2 | GCST90469574 | no MR -> candidate analysis |
| Cerebrospinal fluid protein IL1R1 levels | 5e-42 | rs11685537 | 1 | GCST90944793 | no MR -> candidate analysis |
| …and 18 more traits (see JSON) |
Top diseases by Open Targets association (of 457 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| inflammatory bowel disease | 0.641 | — | common-variant locus | MR: beta=0.153, p=1.37e-09 (cis) |
| asthma | 0.608 | — | common-variant locus | MR: beta=-0.0756, p=4.20e-05 (cis) |
| pneumonia | 0.507 | — | common-variant locus | no MR -> candidate analysis |
| ulcerative colitis | 0.444 | — | common-variant locus | MR: beta=0.196, p=7.61e-10 (cis) |
| infectious meningitis | 0.417 | — | common-variant locus | no MR -> candidate analysis |
| chronic rhinosinusitis | 0.272 | — | common-variant locus | no MR -> candidate analysis |
| Meniere disease | 0.2 | — | common-variant locus | no MR -> candidate analysis |
| gout | 0.215 | — | common-variant locus | MR: beta=0.049, p=0.316 (cis) |
| body weight gain | 0.202 | — | common-variant locus | no MR -> candidate analysis |
| eye disorder | 0.174 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.068 | — | common-variant locus | no MR -> candidate analysis |
| Parkinson disease | 0.044 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.5e-18, LOEUF=1.49 — LoF-tolerant |
| GWAS Catalog | 119 unique SNPs / 208 rows |
| ClinVar | 106 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 457 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL1R2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 106 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 53 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P27930 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000115590/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL1R2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL1R2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL1R2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL1R2 — GWAS Catalog search API (live; release not exposed)