Protein Dossier — IL1RAP (Interleukin-1 receptor accessory protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: anxiety or panic attacks |
0.0918 |
0.0195 |
2.39e-06 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Ankle |
0.0567 |
0.02 |
0.00453 |
Wald ratio |
1 |
cis |
NA |
| Age at menarche |
-0.0141 |
0.00648 |
0.03 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypopituitarism |
0.223 |
0.109 |
0.0407 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.0533 |
0.0262 |
0.0415 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
0.0343 |
0.0168 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
0.0333 |
0.0167 |
0.0464 |
Wald ratio |
1 |
cis |
NA |
| Neo-extraversion |
-0.16 |
0.0814 |
0.0486 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
-0.076 |
0.0389 |
0.0505 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.192 |
0.0982 |
0.0508 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: H25 Senile cataract |
-0.0584 |
0.03 |
0.0513 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: prostate cancer |
0.0534 |
0.0275 |
0.0522 |
Wald ratio |
1 |
cis |
NA |
| …and 94 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2630_12_2 |
IL-1 R AcP |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
80 association rows across 29 traits (72 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Interleukin-1 Receptor accessory protein levels |
5e-2655 |
rs7642797 |
18 |
GCST90248049 |
no MR -> candidate analysis |
| Interleukin-1 Receptor accessory protein levels (IL1RAP.2630 |
8e-720 |
rs34908328 |
3 |
GCST90241575 |
no MR -> candidate analysis |
| Blood protein levels |
2e-567 |
rs724609 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Interleukin-1 Receptor accessory protein (analyte X14048.7) |
4e-381 |
rs6444442 |
1 |
GCST90422429 |
no MR -> candidate analysis |
| Interleukin-1 Receptor accessory protein (analyte X2630.12) |
7e-369 |
rs6444442 |
1 |
GCST90425395 |
no MR -> candidate analysis |
| IL1RAP protein levels |
1e-275 |
rs11927365 |
24 |
GCST90453382 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein IL1RAP levels |
2e-265 |
rs6444442 |
1 |
GCST90944794 |
no MR -> candidate analysis |
| Serum levels of protein IL1RAP |
5e-203 |
rs3796293 |
4 |
GCST90087741 |
no MR -> candidate analysis |
| Protein quantitative trait loci |
1e-119 |
rs1024943 |
1 |
GCST010900 |
no MR -> candidate analysis |
| Protein levels in obesity |
5e-66 |
rs6444444 |
1 |
GCST010196 |
no MR -> candidate analysis |
| Synaptotagmin-9 protein levels (SomaScan ID:14048-7) |
4e-32 |
rs4686558 |
1 |
GCST90443954 |
no MR -> candidate analysis |
| Uncharacterized protein C21orf59 protein levels (SomaScan ID |
1e-31 |
rs4686558 |
1 |
GCST90443462 |
no MR -> candidate analysis |
| …and 17 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 288 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| response to antihypertensive drug |
0.428 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.407 |
— |
common-variant locus |
no MR -> candidate analysis |
| pathological myopia |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
| myopia |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
| insomnia |
0.11 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 5 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (IL-33 receptor (ST2)) |
| gnomAD constraint |
pLI=1.7e-06, LOEUF=0.764 — LoF-tolerant |
| GWAS Catalog |
74 unique SNPs / 148 rows |
| ClinVar |
107 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 288 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL1RAP’ and resolved to ‘IL-33 receptor (ST2)’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 107 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 29 traits by best p-value, aggregated from 80 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9NPH3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000196083/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4804256/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL1RAP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL1RAP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL1RAP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL1RAP — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:14:12 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none