Protein Dossier — IL1RL1 (Interleukin-1 receptor-like 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Crohn’s disease |
0.127 |
0.0142 |
4.01e-19 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.0986 |
0.0118 |
5.37e-17 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
0.0929 |
0.0199 |
2.92e-06 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
0.0639 |
0.0149 |
1.71e-05 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb |
0.0682 |
0.0202 |
7.13e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
-0.143 |
0.0476 |
0.00266 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
-0.0351 |
0.0121 |
0.00365 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.0234 |
0.00814 |
0.00409 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I30 Acute pericarditis |
0.321 |
0.119 |
0.0071 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.139 |
0.0544 |
0.0108 |
Wald ratio |
1 |
cis |
NA |
| Glioma |
-0.124 |
0.0522 |
0.0175 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
0.0959 |
0.0413 |
0.0203 |
Wald ratio |
1 |
cis |
NA |
| …and 105 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4234_8_2 |
IL-1 R4 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
253 association rows across 103 traits (243 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL1RL1 levels |
9e-4422 |
rs12470864 |
7 |
GCST90859979 |
no MR -> candidate analysis |
| ST2 protein levels |
7e-1635 |
rs13020553 |
2 |
GCST90012040 |
no MR -> candidate analysis |
| Interleukin-1 receptor-like 1 levels |
5e-1125 |
rs10179654 |
14 |
GCST90248051 |
no MR -> candidate analysis |
| Interleukin-18 receptor 1 (analyte X3446.7) levels |
5e-611 |
rs12712135 |
1 |
GCST90425769 |
no MR -> candidate analysis |
| Interleukin-18 receptor 1 (analyte X14079.14) levels |
1e-576 |
rs12712135 |
1 |
GCST90422451 |
no MR -> candidate analysis |
| Interleukin-1 receptor-like 1 levels (IL1RL1.4234.8.2) |
3e-391 |
rs10179654 |
3 |
GCST90241581 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein IL18R1 levels |
5e-367 |
rs12996505 |
1 |
GCST90943509 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein IL1RL1 levels |
1e-341 |
rs10178436 |
1 |
GCST90944795 |
no MR -> candidate analysis |
| Serum levels of protein IL1RL1 |
1e-296 |
rs11676124 |
2 |
GCST90088634 |
no MR -> candidate analysis |
| eosinophil (fraction, mean, inv-norm transformed) |
2e-269 |
rs13019081 |
3 |
GCST90475300 |
no MR -> candidate analysis |
| eosinophil (absolute count, mean, inv-norm transformed) |
8e-257 |
rs1420101 |
3 |
GCST90475291 |
no MR -> candidate analysis |
| Blood protein levels in cardiovascular risk |
6e-254 |
rs1420101 |
1 |
GCST009731 |
no MR -> candidate analysis |
| …and 91 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 540 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| asthma |
0.911 |
— |
common-variant locus |
MR: beta=-0.0234, p=0.00409 (cis) |
| allergic disease |
0.848 |
— |
common-variant locus |
no MR -> candidate analysis |
| allergic rhinitis |
0.844 |
— |
common-variant locus |
MR: beta=-0.0351, p=0.00365 (cis) |
| childhood onset asthma |
0.826 |
— |
common-variant locus |
no MR -> candidate analysis |
| respiratory system disorder |
0.811 |
— |
common-variant locus |
no MR -> candidate analysis |
| Wheezing |
0.808 |
— |
common-variant locus |
no MR -> candidate analysis |
| Ascending aortic dissection |
0.801 |
— |
established (curated) |
no MR -> candidate analysis |
| adult onset asthma |
0.785 |
— |
common-variant locus |
no MR -> candidate analysis |
| Eczematoid dermatitis |
0.756 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.54 |
— |
common-variant locus |
no MR -> candidate analysis |
| rhinitis |
0.705 |
— |
common-variant locus |
MR: beta=-0.0351, p=0.00365 (cis) |
| atopic eczema |
0.67 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormal thrombosis |
0.696 |
— |
common-variant locus |
no MR -> candidate analysis |
| nasal cavity polyp |
0.688 |
— |
common-variant locus |
no MR -> candidate analysis |
| Chronic Obstructive Asthma |
0.668 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (IL-33 receptor (ST2)) |
| gnomAD constraint |
pLI=4.9e-07, LOEUF=0.845 — LoF-tolerant |
| GWAS Catalog |
183 unique SNPs / 490 rows |
| ClinVar |
141 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 540 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL1RL1’ and resolved to ‘IL-33 receptor (ST2)’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 141 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 103 traits by best p-value, aggregated from 253 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q01638 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000115602/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4804256/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL1RL1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL1RL1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL1RL1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL1RL1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:14:31 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none