Protein Dossier — IL1RL2 (Interleukin-1 receptor-like 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
0.291 |
0.0918 |
0.00152 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.255 |
0.0809 |
0.00159 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders |
0.294 |
0.113 |
0.00934 |
Wald ratio |
1 |
cis |
NA |
| 2hr glucose |
0.209 |
0.0847 |
0.0134 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.111 |
0.0474 |
0.0197 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
0.258 |
0.112 |
0.0216 |
Wald ratio |
1 |
cis |
NA |
| Paget’s disease |
-0.559 |
0.251 |
0.0261 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Arm |
0.199 |
0.0913 |
0.0293 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
-0.11 |
0.0509 |
0.0311 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Glaucoma |
0.154 |
0.0794 |
0.0518 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
0.131 |
0.0685 |
0.0556 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.0213 |
0.0112 |
0.0577 |
Wald ratio |
1 |
cis |
NA |
| …and 73 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2994_71_2 |
IL-1Rrp2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
50 association rows across 24 traits (48 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL1RL2 levels |
3e-796 |
rs4851553 |
2 |
GCST90859762 |
no MR -> candidate analysis |
| IL1RL1 protein levels |
2e-125 |
rs9808381 |
1 |
GCST90469574 |
no MR -> candidate analysis |
| IL1RL2 protein levels |
7e-86 |
rs186799902 |
8 |
GCST90469575 |
no MR -> candidate analysis |
| Eosinophil count |
5e-82 |
rs1997502 |
1 |
GCST007065 |
no MR -> candidate analysis |
| Interleukin-1 receptor-like 2 levels |
2e-63 |
rs1922291 |
9 |
GCST90179331 |
no MR -> candidate analysis |
| IL18R1 protein levels |
2e-55 |
rs55948744 |
8 |
GCST90469565 |
no MR -> candidate analysis |
| Circulating IL1R2 levels |
4e-55 |
rs7606834 |
1 |
GCST90859972 |
no MR -> candidate analysis |
| Interleukin-1 receptor type 1 levels |
1e-29 |
rs145305012 |
1 |
GCST90161576 |
no MR -> candidate analysis |
| Interleukin-1 receptor-like 1 levels |
2e-29 |
rs2302612 |
2 |
GCST90162020 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein IL1RL2 levels |
1e-25 |
rs3771199 |
1 |
GCST90942307 |
no MR -> candidate analysis |
| Asthma (childhood onset) |
1e-19 |
rs2302621 |
1 |
GCST009841 |
no MR -> candidate analysis |
| Circulating IL1R1 levels |
9e-19 |
rs11887842 |
1 |
GCST90859959 |
no MR -> candidate analysis |
| …and 12 more traits (see JSON) |
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|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 313 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| asthma |
0.68 |
— |
common-variant locus |
MR: beta=0.0291, p=0.329 (cis) |
| Ascending aortic dissection |
0.684 |
— |
established (curated) |
no MR -> candidate analysis |
| atopic eczema |
0.5 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic rhinosinusitis |
0.466 |
— |
common-variant locus |
no MR -> candidate analysis |
| nephrotic syndrome |
0.448 |
— |
common-variant locus |
no MR -> candidate analysis |
| peptic ulcer disease |
0.441 |
— |
common-variant locus |
no MR -> candidate analysis |
| transient ischemic attack |
0.421 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.038 |
— |
common-variant locus |
no MR -> candidate analysis |
| infection |
0.319 |
— |
common-variant locus |
no MR -> candidate analysis |
| Wheezing |
0.163 |
— |
common-variant locus |
no MR -> candidate analysis |
| endometriosis |
0.156 |
— |
common-variant locus |
no MR -> candidate analysis |
| intestinal obstruction |
0.064 |
— |
common-variant locus |
no MR -> candidate analysis |
| gout |
0.129 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 13 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (IL36 receptor) |
| gnomAD constraint |
pLI=5.4e-24, LOEUF=1.25 — LoF-tolerant |
| GWAS Catalog |
160 unique SNPs / 390 rows |
| ClinVar |
129 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 313 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL1RL2’ and resolved to ‘IL36 receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 129 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 24 traits by best p-value, aggregated from 50 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9HB29 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000115598/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4665591/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL1RL2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL1RL2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL1RL2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL1RL2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:14:49 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none