MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Myocardial infarction | 0.264 | 0.0558 | 2.21e-06 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.0381 | 0.011 | 5.49e-04 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | 0.173 | 0.0514 | 7.34e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | 0.236 | 0.0731 | 0.00125 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.271 | 0.0867 | 0.00179 | Wald ratio | 1 | cis | NA |
| Parkinson’s disease | -0.645 | 0.219 | 0.00325 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I30 Acute pericarditis | 0.923 | 0.327 | 0.00473 | Wald ratio | 1 | cis | NA |
| Total cholesterol | 0.0755 | 0.0267 | 0.00475 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) | 0.324 | 0.123 | 0.00849 | Wald ratio | 1 | cis | NA |
| LDL cholesterol | 0.0676 | 0.0273 | 0.0131 | Wald ratio | 1 | cis | NA |
| Weight | -0.0275 | 0.0113 | 0.0147 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M54 Dorsalgia | 0.199 | 0.0819 | 0.0154 | Wald ratio | 1 | cis | NA |
| …and 104 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
161 association rows across 89 traits (111 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| IL1RN protein levels | 3e-249 | rs55709272 | 2 | GCST90469576 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 7e-110 | rs4368340 | 2 | GCST90838669 | no MR -> candidate analysis |
| IL1R1 protein levels | 4e-109 | rs55709272 | 1 | GCST90469571 | no MR -> candidate analysis |
| C-reactive protein levels | 3e-102 | rs55709272 | 4 | GCST009777 | no MR -> candidate analysis |
| white blood cell count (WBC, minimum, inv-norm transformed) | 1e-99 | rs55709272 | 1 | GCST90476457 | no MR -> candidate analysis |
| C-reactive protein levels (UKB data field 30710) | 8e-86 | rs55709272 | 1 | GCST90468064 | no MR -> candidate analysis |
| C-reactive protein levels (MTAG) | 3e-85 | rs55709272 | 3 | GCST90179146 | no MR -> candidate analysis |
| neutrophil (absolute count, minimum, inv-norm transformed) | 7e-79 | rs55709272 | 1 | GCST90475532 | no MR -> candidate analysis |
| C-reactive protein | 2e-73 | rs55709272 | 1 | GCST90018950 | no MR -> candidate analysis |
| neutrophil (absolute count, mean, inv-norm transformed) | 2e-73 | rs55709272 | 1 | GCST90475529 | no MR -> candidate analysis |
| White blood cell count | 1e-57 | rs55709272 | 1 | GCST007070 | no MR -> candidate analysis |
| Neutrophil count | 2e-56 | rs55709272 | 3 | GCST90018968 | no MR -> candidate analysis |
| …and 77 more traits (see JSON) |
Top diseases by Open Targets association (of 1385 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| sterile multifocal osteomyelitis with periostitis and pustulosis | 0.823 | — | established (curated) | no MR -> candidate analysis |
| gout | 0.894 | — | common-variant locus | MR: beta=-0.342, p=0.0274 (cis) |
| abdominal aortic aneurysm | 0.728 | — | common-variant locus | no MR -> candidate analysis |
| ischemic stroke | 0.588 | — | common-variant locus | MR: beta=-0.0781, p=0.358 (cis) |
| coronary artery disorder | 0.588 | — | common-variant locus | no MR -> candidate analysis |
| venous thromboembolism | 0.587 | — | common-variant locus | no MR -> candidate analysis |
| autoinflammatory syndrome | 0.552 | — | established (curated) | no MR -> candidate analysis |
| hypothyroidism | 0.486 | — | common-variant locus | no MR -> candidate analysis |
| hypertrophic cardiomyopathy | 0.448 | — | common-variant locus | no MR -> candidate analysis |
| testicular hydrocele | 0.386 | — | common-variant locus | no MR -> candidate analysis |
| cervix erosion | 0.376 | — | common-variant locus | no MR -> candidate analysis |
| hereditary disease | 0.311 | — | established (curated) | no MR -> candidate analysis |
| gastric cancer | 0.278 | — | established (curated) | no MR -> candidate analysis |
| quality of life cycle | 0.271 | — | common-variant locus | no MR -> candidate analysis |
| Cervical ectropion | 0.261 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Interleukin-1 receptor antagonist protein) |
| gnomAD constraint | pLI=0.002, LOEUF=1.24 — LoF-tolerant |
| GWAS Catalog | 163 unique SNPs / 390 rows |
| ClinVar | 280 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 1385 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL1RN’ and resolved to ‘Interleukin-1 receptor antagonist protein’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 280 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 89 traits by best p-value, aggregated from 161 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P18510 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000136689/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4523191/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL1RN — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL1RN — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL1RN%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=IL1RN — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/IL1RN — GWAS Catalog search API (live; release not exposed)