Protein Dossier — IL23R (Interleukin-23 receptor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Inflammatory bowel disease |
1.5 |
0.0546 |
2.21e-166 |
Wald ratio |
1 |
cis |
0.753 |
| Crohn’s disease |
1.84 |
0.0707 |
5.80e-149 |
Wald ratio |
1 |
cis |
0.993 |
| Ulcerative colitis |
1.14 |
0.0686 |
4.34e-62 |
Wald ratio |
1 |
cis |
0.82 |
| Non-cancer illness code self-reported: psoriasis |
0.431 |
0.0704 |
9.48e-10 |
Wald ratio |
1 |
cis |
0.971 |
| Non-cancer illness code self-reported: ankylosing spondylitis |
0.524 |
0.131 |
6.19e-05 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hiatus hernia |
0.177 |
0.0632 |
0.00513 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gout |
0.186 |
0.0803 |
0.0208 |
Wald ratio |
1 |
cis |
NA |
| Primary sclerosing cholangitis |
0.324 |
0.15 |
0.0305 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
0.148 |
0.0699 |
0.0345 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
0.0941 |
0.0454 |
0.0383 |
Wald ratio |
1 |
cis |
NA |
| Femoral neck bone mineral density |
-0.0703 |
0.0348 |
0.0435 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis |
0.13 |
0.0653 |
0.0459 |
Wald ratio |
1 |
cis |
NA |
| …and 60 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5088_175_3 |
IL-23 R |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
113 association rows across 44 traits (94 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Inflammatory bowel disease |
2e-170 |
rs7547569 |
9 |
GCST003043 |
MR: beta=1.5, p=2.21e-166 (cis) |
| Crohn’s disease |
1e-159 |
rs7517847 |
19 |
GCST003044 |
MR: beta=1.84, p=5.80e-149 (cis) |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn |
1e-143 |
rs80174646 |
4 |
GCST005537 |
no MR -> candidate analysis |
| Ulcerative colitis |
4e-62 |
rs80174646 |
13 |
GCST003045 |
MR: beta=1.14, p=4.34e-62 (cis) |
| Crohn’s disease vs rheumatoid arthritis (ordinary least squa |
5e-43 |
rs7517847 |
1 |
GCST90016610 |
no MR -> candidate analysis |
| Interleukin-23 receptor levels |
1e-32 |
rs1358748 |
3 |
GCST90137730 |
no MR -> candidate analysis |
| Ankylosing spondylitis |
6e-28 |
rs11209026 |
4 |
GCST005529 |
MR: beta=0.524, p=6.19e-05 (cis) |
| Regional enteritis (PheCode 555.1) |
9e-27 |
rs11805303 |
2 |
GCST90480317 |
no MR -> candidate analysis |
| Psoriasis |
1e-26 |
rs9988642 |
11 |
GCST005527 |
MR: beta=0.431, p=9.48e-10 (cis) |
| Inflammatory bowel disease and other gasteroenteritis and co |
1e-26 |
rs113935720 |
2 |
GCST90476065 |
no MR -> candidate analysis |
| Psoriasis and related disorder (PheCode 696) |
8e-23 |
rs11581607 |
2 |
GCST90476186 |
no MR -> candidate analysis |
| Psoriasis (PheCode 696.4) |
2e-22 |
rs11581607 |
2 |
GCST90476187 |
no MR -> candidate analysis |
| …and 32 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 424 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| inflammatory bowel disease |
0.919 |
— |
common-variant locus |
MR: beta=1.5, p=2.21e-166 (cis) |
| psoriasis |
0.898 |
— |
common-variant locus |
MR: beta=0.431, p=9.48e-10 (cis) |
| Crohn disease |
0.911 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.904 |
— |
common-variant locus |
MR: beta=1.14, p=4.34e-62 (cis) |
| enteritis |
0.834 |
— |
common-variant locus |
no MR -> candidate analysis |
| ankylosing spondylitis |
0.824 |
— |
common-variant locus |
MR: beta=0.524, p=6.19e-05 (cis) |
| sarcoidosis |
0.784 |
— |
common-variant locus |
no MR -> candidate analysis |
| colitis |
0.752 |
— |
common-variant locus |
MR: beta=1.14, p=4.34e-62 (cis) |
| psoriasis vulgaris |
0.76 |
— |
common-variant locus |
no MR -> candidate analysis |
| autoimmune disease |
0.738 |
— |
common-variant locus |
no MR -> candidate analysis |
| skin disorder |
0.724 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative proctosigmoiditis |
0.681 |
— |
common-variant locus |
no MR -> candidate analysis |
| seborrheic dermatitis |
0.662 |
— |
common-variant locus |
no MR -> candidate analysis |
| intestinal disorder |
0.652 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.626 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Interleukin-23 receptor) |
| gnomAD constraint |
pLI=8.4e-07, LOEUF=0.796 — LoF-tolerant |
| GWAS Catalog |
122 unique SNPs / 311 rows |
| ClinVar |
476 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
2 clinical annotations across 2 drugs |
phenome — Top 30 of 424 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL23R’ and resolved to ‘Interleukin-23 receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 476 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 44 traits by best p-value, aggregated from 113 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q5VWK5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162594/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4296013/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL23R — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL23R — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL23R%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=IL23R — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/IL23R — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:15:06 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none