Protein Dossier — IL25 (Interleukin-25)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
-0.0112 |
0.00322 |
4.85e-04 |
Wald ratio |
1 |
trans |
NA |
| Body mass index (BMI) |
-0.0121 |
0.00365 |
9.35e-04 |
Wald ratio |
1 |
trans |
NA |
| High grade serous ovarian cancer |
0.0702 |
0.0238 |
0.00324 |
Wald ratio |
1 |
trans |
NA |
| Thyroid cancer |
-0.405 |
0.138 |
0.00333 |
Wald ratio |
1 |
trans |
NA |
| Diastolic blood pressure automated reading |
0.0108 |
0.00373 |
0.00377 |
Wald ratio |
1 |
trans |
NA |
| Ovarian cancer |
0.0548 |
0.0201 |
0.00636 |
Wald ratio |
1 |
trans |
NA |
| Hirschsprung’s disease |
-0.619 |
0.238 |
0.00935 |
Wald ratio |
1 |
trans |
NA |
| Depressive symptoms |
0.0146 |
0.0061 |
0.0164 |
Wald ratio |
1 |
trans |
NA |
| Systolic blood pressure automated reading |
0.00891 |
0.00373 |
0.017 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: gout |
-0.075 |
0.033 |
0.0231 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] |
-0.0605 |
0.0279 |
0.0303 |
Wald ratio |
1 |
trans |
NA |
| Schizophrenia |
0.0351 |
0.0162 |
0.0304 |
Wald ratio |
1 |
trans |
NA |
| …and 91 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4137_57_2 |
IL-17E |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
6 association rows across 6 traits (4 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Embryonal Fyn-associated substrate levels |
2e-12 |
rs10137082 |
1 |
GCST90247405 |
no MR -> candidate analysis |
| Height (baseline) |
1e-11 |
rs3759609 |
1 |
GCST90565843 |
no MR -> candidate analysis |
| PR interval |
7e-10 |
rs11465506 |
1 |
GCST007045 |
no MR -> candidate analysis |
| Blood pressure (pleiotropy model 1 DBP adjusted for estimate |
3e-8 |
rs146602111 |
1 |
GCST90239828 |
no MR -> candidate analysis |
| Type 1 diabetes |
6e-6 |
rs10137082 |
1 |
GCST001255 |
no MR -> candidate analysis |
| Blood pressure (pleiotropy model 2 SBP adjusted for estimate |
8e-6 |
rs146602111 |
1 |
GCST90239829 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1020 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| atrial fibrillation |
0.053 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0015, LOEUF=1.29 — LoF-tolerant |
| GWAS Catalog |
72 unique SNPs / 144 rows |
| ClinVar |
57 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1020 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL25’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 57 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 6 of 6 traits by best p-value, aggregated from 6 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9H293 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000166090/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL25 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL25 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL25%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL25 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:15:21 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none