Protein Dossier — IL27RA (Interleukin-27 receptor subunit alpha)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Sleep duration |
0.00751 |
0.0026 |
0.00389 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: depression |
0.0322 |
0.0133 |
0.0154 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
-0.0366 |
0.0154 |
0.0172 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M54 Dorsalgia |
0.0548 |
0.0245 |
0.0252 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bone disorder |
0.139 |
0.0621 |
0.0253 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
0.108 |
0.0484 |
0.0261 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: H25 Senile cataract |
0.0766 |
0.0352 |
0.0296 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
-0.0598 |
0.0286 |
0.0364 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hiatus hernia |
0.0431 |
0.0209 |
0.0396 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.114 |
0.0584 |
0.0509 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
-0.101 |
0.0555 |
0.0674 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Diabetes related eye disease |
0.0709 |
0.0398 |
0.0744 |
Wald ratio |
1 |
cis |
NA |
| …and 62 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5132_71_3 |
TCCR |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
28 association rows across 20 traits (28 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Interleukin-27 receptor subunit alpha levels |
4e-542 |
rs35026308 |
5 |
GCST90248067 |
no MR -> candidate analysis |
| Interleukin-27 receptor subunit alpha levels (IL27RA.5132.71 |
4e-239 |
rs35026308 |
1 |
GCST90241627 |
no MR -> candidate analysis |
| Serum levels of protein IL27RA |
3e-199 |
rs35026308 |
1 |
GCST90088948 |
no MR -> candidate analysis |
| Mitochondrial ubiquitin ligase activator of NFKB 1:Cytoplasm |
4e-25 |
rs35026308 |
1 |
GCST90441052 |
no MR -> candidate analysis |
| Cerebrospinal fluid biomarker levels |
3e-15 |
rs35026308 |
1 |
GCST004000 |
no MR -> candidate analysis |
| Neutrophil percentage of white cells |
1e-14 |
rs35026308 |
1 |
GCST90002399 |
no MR -> candidate analysis |
| Lymphocyte count |
2e-13 |
rs35026308 |
1 |
GCST90002388 |
no MR -> candidate analysis |
| Platelet count |
3e-13 |
rs35018855 |
3 |
GCST90662907 |
no MR -> candidate analysis |
| Lymphocyte count (UKB data field 30120) |
1e-12 |
rs35026308 |
1 |
GCST90468082 |
no MR -> candidate analysis |
| Platelet count (UKB data field 30080) |
1e-12 |
rs2306191 |
1 |
GCST90468095 |
no MR -> candidate analysis |
| Lymphocyte percentage of white cells |
3e-12 |
rs35026308 |
1 |
GCST90002389 |
no MR -> candidate analysis |
| Platelet crit (UKB data field 30090) |
5e-12 |
rs2306191 |
1 |
GCST90468096 |
no MR -> candidate analysis |
| …and 8 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 237 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcohol drinking |
0.054 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=5.1e-16, LOEUF=0.935 — LoF-tolerant |
| GWAS Catalog |
36 unique SNPs / 72 rows |
| ClinVar |
138 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 237 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL27RA’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 138 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 20 traits by best p-value, aggregated from 28 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q6UWB1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104998/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL27RA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL27RA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL27RA%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL27RA — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:15:47 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none