Protein Dossier — IL27 (Interleukin-27 subunit alpha)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Crohn’s disease |
-0.666 |
0.0717 |
1.44e-20 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
-0.515 |
0.0597 |
6.42e-18 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
-0.296 |
0.075 |
8.05e-05 |
Wald ratio |
1 |
cis |
NA |
| Juvenile idiopathic arthritis |
-0.715 |
0.307 |
0.0198 |
Wald ratio |
1 |
cis |
NA |
| Multiple sclerosis |
0.0986 |
0.097 |
0.309 |
Wald ratio |
1 |
cis |
NA |
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2829_19_2 |
IL-27 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
96 association rows across 60 traits (81 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| APOBR protein levels |
3e-234 |
rs12448270 |
2 |
GCST90468334 |
no MR -> candidate analysis |
| Circulating EBI3_IL27 levels |
1e-84 |
rs181209 |
1 |
GCST90859764 |
no MR -> candidate analysis |
| Height |
1e-39 |
rs28698667 |
2 |
GCST90245848 |
no MR -> candidate analysis |
| Circulating SULT1A1 levels |
1e-37 |
rs12448270 |
1 |
GCST90859907 |
no MR -> candidate analysis |
| Drinks per week |
4e-32 |
rs4788084 |
4 |
GCST90243989 |
no MR -> candidate analysis |
| Mean spheric corpuscular volume |
7e-30 |
rs181205 |
1 |
GCST90002397 |
no MR -> candidate analysis |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn |
3e-29 |
rs26528 |
1 |
GCST005537 |
no MR -> candidate analysis |
| Educational attainment (years of education) |
2e-28 |
rs62034319 |
1 |
GCST006442 |
no MR -> candidate analysis |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) |
4e-28 |
rs181205 |
1 |
GCST90468072 |
no MR -> candidate analysis |
| monocyte (fraction, mean, inv-norm transformed) |
1e-26 |
rs181207 |
2 |
GCST90475511 |
no MR -> candidate analysis |
| mean corpuscular hemoglobin concentration (MCHC, mean, inv-n |
3e-26 |
rs181207 |
2 |
GCST90475458 |
no MR -> candidate analysis |
| Mean corpuscular volume (UKB data field 30040) |
8e-25 |
rs4787458 |
1 |
GCST90468086 |
no MR -> candidate analysis |
| …and 48 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 711 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Crohn disease |
0.72 |
— |
common-variant locus |
no MR -> candidate analysis |
| obesity disorder |
0.569 |
— |
common-variant locus |
no MR -> candidate analysis |
| leprosy |
0.533 |
— |
common-variant locus |
no MR -> candidate analysis |
| cystic kidney disease |
0.481 |
— |
common-variant locus |
no MR -> candidate analysis |
| overnutrition |
0.449 |
— |
common-variant locus |
no MR -> candidate analysis |
| psoriasis |
0.406 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.406 |
— |
common-variant locus |
MR: beta=-0.296, p=8.05e-05 (cis) |
| ankylosing spondylitis |
0.406 |
— |
common-variant locus |
no MR -> candidate analysis |
| sclerosing cholangitis |
0.393 |
— |
common-variant locus |
no MR -> candidate analysis |
| inflammatory bowel disease |
0.201 |
— |
common-variant locus |
MR: beta=-0.515, p=6.42e-18 (cis) |
| type 1 diabetes mellitus |
0.138 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian dysfunction |
0.185 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.114 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 13 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.34, LOEUF=0.673 — LoF-tolerant |
| GWAS Catalog |
109 unique SNPs / 253 rows |
| ClinVar |
131 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 711 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL27’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 131 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 60 traits by best p-value, aggregated from 96 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q8NEV9 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000197272/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL27 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL27 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL27%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL27 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:15:35 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none