Protein Dossier — IL5RA (Interleukin-5 receptor subunit alpha)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Nucleus accumbens volume |
-9.93 |
3.33 |
0.0029 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.19 |
0.073 |
0.00931 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
-0.0845 |
0.0332 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: retinal detachment |
0.237 |
0.0975 |
0.015 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.164 |
0.0696 |
0.0188 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
-16 |
7.22 |
0.0264 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Glaucoma |
0.111 |
0.0526 |
0.0345 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Ankle |
0.109 |
0.0538 |
0.0421 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
-0.167 |
0.0932 |
0.0738 |
Wald ratio |
1 |
cis |
NA |
| Pallidum volume |
-10.5 |
5.85 |
0.0739 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.179 |
0.101 |
0.0766 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: H25 Senile cataract |
-0.168 |
0.0956 |
0.0789 |
Wald ratio |
1 |
cis |
NA |
| …and 48 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4491_4_2 |
IL-5 Ra |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
129 association rows across 41 traits (124 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL5RA levels |
6e-715 |
rs77400868 |
6 |
GCST90859717 |
no MR -> candidate analysis |
| IL5RA protein levels |
1e-255 |
rs340829 |
11 |
GCST90469600 |
no MR -> candidate analysis |
| Basophil (fraction, mean, inv-norm transformed) |
1e-160 |
rs163546 |
3 |
GCST90479516 |
no MR -> candidate analysis |
| Interleukin-5 receptor subunit alpha levels |
1e-147 |
rs77400868 |
17 |
GCST90248075 |
no MR -> candidate analysis |
| Basophil (fraction, maximum, inv-norm transformed) |
7e-121 |
rs163546 |
2 |
GCST90479515 |
no MR -> candidate analysis |
| Serum levels of protein IL5RA |
5e-104 |
rs77400868 |
5 |
GCST90088714 |
no MR -> candidate analysis |
| Basophil (fraction, minimum, inv-norm transformed) |
2e-95 |
rs163546 |
2 |
GCST90479517 |
no MR -> candidate analysis |
| Basophil (absolute count, mean, inv-norm transformed) |
8e-77 |
rs163546 |
3 |
GCST90479513 |
no MR -> candidate analysis |
| Basophil (absolute count, maximum, inv-norm transformed) |
2e-65 |
rs163546 |
3 |
GCST90479512 |
no MR -> candidate analysis |
| Eosinophil count |
2e-61 |
rs1695315 |
13 |
GCST90002298 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
1e-50 |
rs1695315 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| eosinophil (absolute count, mean, inv-norm transformed) |
4e-50 |
rs3806680 |
2 |
GCST90475291 |
no MR -> candidate analysis |
| …and 29 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 245 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| skull disorder |
0.512 |
— |
common-variant locus |
no MR -> candidate analysis |
| deficiency anemia |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| aneurysm |
0.259 |
— |
common-variant locus |
no MR -> candidate analysis |
| restless legs syndrome |
0.123 |
— |
common-variant locus |
no MR -> candidate analysis |
| Respiratory insufficiency |
0.119 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.114 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian neoplasm |
0.111 |
— |
common-variant locus |
no MR -> candidate analysis |
| placenta praevia |
0.101 |
— |
common-variant locus |
no MR -> candidate analysis |
| duodenal ulcer |
0.098 |
— |
common-variant locus |
no MR -> candidate analysis |
| nutritional deficiency disease |
0.097 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental retention |
0.097 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 11 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Interleukin-5 receptor subunit alpha) |
| gnomAD constraint |
pLI=7.2e-17, LOEUF=1.24 — LoF-tolerant |
| GWAS Catalog |
104 unique SNPs / 222 rows |
| ClinVar |
183 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 245 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘IL5RA’ and resolved to ‘Interleukin-5 receptor subunit alpha’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 183 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 41 traits by best p-value, aggregated from 129 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q01344 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000091181/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3580483/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/IL5RA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL5RA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL5RA%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL5RA — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:16:05 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none