Protein Dossier — IL7R (Interleukin-7 receptor subunit alpha)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Inflammatory bowel disease |
0.104 |
0.0247 |
2.48e-05 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.0948 |
0.0233 |
4.80e-05 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0574 |
0.0153 |
1.69e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
0.0784 |
0.0219 |
3.49e-04 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
0.102 |
0.0309 |
9.04e-04 |
Wald ratio |
1 |
cis |
NA |
| Crohn’s disease |
0.0964 |
0.0298 |
0.00123 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0223 |
0.00746 |
0.00279 |
Wald ratio |
1 |
cis |
NA |
| Height |
-0.0198 |
0.00706 |
0.00511 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0699 |
0.0268 |
0.00918 |
Wald ratio |
1 |
cis |
NA |
| Juvenile idiopathic arthritis |
0.323 |
0.127 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Lung cancer |
-0.0971 |
0.041 |
0.018 |
Wald ratio |
1 |
cis |
NA |
| Happiness |
0.0168 |
0.00714 |
0.0182 |
Wald ratio |
1 |
cis |
NA |
| …and 109 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5089_11_3 |
IL-7 Ra |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
258 association rows across 144 traits (242 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating IL7R levels |
1e-4083 |
rs11742270 |
4 |
GCST90860451 |
no MR -> candidate analysis |
| ICAM2/IL7R protein level ratio |
3e-3651 |
rs6897932 |
1 |
GCST90315117 |
no MR -> candidate analysis |
| IL7R protein levels |
8e-206 |
rs182158522 |
12 |
GCST90469605 |
no MR -> candidate analysis |
| Lymphocyte count |
3e-144 |
rs11567699 |
7 |
GCST90002320 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
1e-118 |
rs11567701 |
2 |
GCST90838669 |
no MR -> candidate analysis |
| Atopic dermatitis |
3e-99 |
rs10214273 |
6 |
GCST90244787 |
no MR -> candidate analysis |
| Lymphocyte count (UKB data field 30120) |
3e-86 |
rs1053496 |
1 |
GCST90468082 |
no MR -> candidate analysis |
| Eosinophil count |
2e-66 |
rs1961220 |
8 |
GCST90002302 |
no MR -> candidate analysis |
| Lymphocyte percentage of white cells |
1e-63 |
rs11567701 |
2 |
GCST90002389 |
no MR -> candidate analysis |
| Lymphocyte percentage (UKB data field 30180) |
4e-61 |
rs11567701 |
1 |
GCST90468083 |
no MR -> candidate analysis |
| Eczema |
2e-59 |
rs6881706 |
3 |
GCST007075 |
MR: beta=0.0584, p=0.146 (cis) |
| Eosinophill percentage (UKB data field 30210) |
6e-53 |
rs4594881 |
1 |
GCST90468069 |
no MR -> candidate analysis |
| …and 132 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 872 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| immunodeficiency 104 |
0.889 |
— |
established (curated) |
no MR -> candidate analysis |
| asthma |
0.957 |
— |
common-variant locus |
MR: beta=0.0574, p=1.69e-04 (cis) |
| multiple sclerosis |
0.804 |
— |
common-variant locus |
no MR -> candidate analysis |
| T-B+ severe combined immunodeficiency due to JAK3 deficiency |
0.959 |
— |
established (curated) |
no MR -> candidate analysis |
| hypothyroidism |
0.935 |
— |
common-variant locus |
MR: beta=0.0948, p=4.80e-05 (cis) |
| Omenn syndrome |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| allergic rhinitis |
0.904 |
— |
common-variant locus |
MR: beta=0.0784, p=3.49e-04 (cis) |
| atopic eczema |
0.903 |
— |
common-variant locus |
no MR -> candidate analysis |
| Eczematoid dermatitis |
0.897 |
— |
common-variant locus |
no MR -> candidate analysis |
| primary biliary cholangitis |
0.894 |
— |
common-variant locus |
no MR -> candidate analysis |
| allergic disease |
0.875 |
— |
common-variant locus |
no MR -> candidate analysis |
| dermatitis |
0.866 |
— |
common-variant locus |
no MR -> candidate analysis |
| severe combined immunodeficiency |
0.858 |
— |
established (curated) |
no MR -> candidate analysis |
| skin disorder |
0.846 |
— |
common-variant locus |
no MR -> candidate analysis |
| respiratory system disorder |
0.813 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=4e-11, LOEUF=1.06 — LoF-tolerant |
| GWAS Catalog |
124 unique SNPs / 323 rows |
| ClinVar |
635 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 872 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL7R’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 635 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 144 traits by best p-value, aggregated from 258 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P16871 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000168685/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL7R — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL7R — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL7R%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/IL7R — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:16:54 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none