Protein Dossier — IL7 (Interleukin-7)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.165 |
0.046 |
3.32e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders |
0.382 |
0.115 |
8.93e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
1.02 |
0.355 |
0.00396 |
Wald ratio |
1 |
cis |
NA |
| Multiple sclerosis |
-0.193 |
0.0793 |
0.0147 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.46 |
0.202 |
0.023 |
Wald ratio |
1 |
cis |
NA |
| Platelet count |
4.11 |
1.9 |
0.0309 |
Wald ratio |
1 |
cis |
NA |
| Femoral neck bone mineral density |
-0.0789 |
0.0368 |
0.0322 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
0.0198 |
0.00952 |
0.0378 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.106 |
0.0526 |
0.0432 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.282 |
0.139 |
0.0434 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: anxiety or panic attacks |
-0.291 |
0.144 |
0.0437 |
Wald ratio |
1 |
cis |
NA |
| Fasting proinsulin |
-0.0647 |
0.0324 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| …and 89 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4140_3_2 |
IL-7 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
50 association rows across 33 traits (50 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Hematological traits (multi-trait analysis) |
1e-147 |
rs111205650 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| Lymphocyte count |
1e-116 |
rs1441850 |
9 |
GCST90002316 |
no MR -> candidate analysis |
| Lymphocyte count (UKB data field 30120) |
4e-77 |
rs1441850 |
2 |
GCST90468082 |
no MR -> candidate analysis |
| Lymphocyte percentage of white cells |
4e-65 |
rs2919917 |
2 |
GCST90002389 |
no MR -> candidate analysis |
| Platelet-to-lymphocyte ratio |
1e-39 |
rs1441850 |
1 |
GCST90056184 |
no MR -> candidate analysis |
| Neutrophil percentage of white cells |
5e-39 |
rs1483573 |
2 |
GCST90002399 |
no MR -> candidate analysis |
| Neutrophils and lymphocytes in blood (confirmatory factor an |
3e-33 |
rs2953475 |
1 |
GCST90309369 |
no MR -> candidate analysis |
| Lymphocyte-to-monocyte ratio |
2e-32 |
rs1441850 |
1 |
GCST90056181 |
no MR -> candidate analysis |
| Neutrophill percentage (UKB data field 30200) |
3e-30 |
rs1483573 |
1 |
GCST90468093 |
no MR -> candidate analysis |
| Neutrophil-to-lymphocyte ratio |
6e-30 |
rs2953475 |
7 |
GCST90056182 |
no MR -> candidate analysis |
| Circulating CD6 levels |
2e-20 |
rs2919917 |
1 |
GCST90859855 |
no MR -> candidate analysis |
| KLRB1 protein levels |
6e-18 |
rs1483573 |
1 |
GCST90469709 |
no MR -> candidate analysis |
| …and 21 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 936 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| epidermodysplasia verruciformis |
0.733 |
— |
established (curated) |
no MR -> candidate analysis |
| basal cell carcinoma |
0.431 |
— |
common-variant locus |
MR: beta=0.208, p=0.0476 (cis) |
| systemic lupus erythematosus |
0.4 |
— |
common-variant locus |
no MR -> candidate analysis |
| cancer |
0.365 |
— |
common-variant locus |
MR: beta=0.165, p=3.32e-04 (cis) |
| cardiomyopathy |
0.394 |
— |
common-variant locus |
MR: beta=1.02, p=0.00396 (cis) |
| autoimmune disorder of musculoskeletal system |
0.4 |
— |
common-variant locus |
no MR -> candidate analysis |
| Genu valgum |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| biliary tract disorder |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| tricuspid valve disorder |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| Genu varum |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| color vision disorder |
0.389 |
— |
common-variant locus |
no MR -> candidate analysis |
| bone fracture |
0.36 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hypercholesterolemia |
0.356 |
— |
common-variant locus |
MR: beta=-0.0588, p=0.0929 (cis) |
| alcohol drinking |
0.354 |
— |
common-variant locus |
no MR -> candidate analysis |
| knee fracture |
0.346 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1, LOEUF=0.359 — LoF-INTOLERANT |
| GWAS Catalog |
58 unique SNPs / 116 rows |
| ClinVar |
135 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 936 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘IL7’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 135 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 33 traits by best p-value, aggregated from 50 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P13232 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104432/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/IL7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/IL7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=IL7%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=IL7 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/IL7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:16:40 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none