MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Bulimia nervosa | -0.0786 | 0.0274 | 0.00415 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | 0.116 | 0.0412 | 0.00479 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | 0.0544 | 0.0197 | 0.00565 | Wald ratio | 1 | cis | NA |
| Fasting glucose | 0.075 | 0.0293 | 0.0104 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.014 | 0.00555 | 0.0118 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: B37 Candidiasis | 0.49 | 0.196 | 0.0127 | Wald ratio | 1 | cis | NA |
| Years of schooling | -0.0219 | 0.00914 | 0.0164 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0751 | 0.0322 | 0.0195 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0152 | 0.00657 | 0.0205 | Wald ratio | 1 | cis | NA |
| Large vessel disease | 0.212 | 0.0947 | 0.025 | Wald ratio | 1 | cis | NA |
| Serum creatinine (eGFRcrea) | 0.00512 | 0.00238 | 0.0313 | Wald ratio | 1 | cis | NA |
| Pancreatic cancer | 0.286 | 0.133 | 0.0322 | Wald ratio | 1 | cis | NA |
| …and 113 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
63 association rows across 38 traits (58 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-257 | rs112495211 | 1 | GCST90321120 | no MR -> candidate analysis |
| Type II inositol 1,4,5-trisphosphate 5-phosphatase levels | 1e-115 | rs61776676 | 2 | GCST90249876 | no MR -> candidate analysis |
| Hypothyroidism | 3e-25 | rs35978921 | 4 | GCST90572791 | no MR -> candidate analysis |
| Alzheimer’s disease or family history of Alzheimer’s disease | 2e-23 | rs1488544082 | 2 | GCST90624094 | no MR -> candidate analysis |
| Pulse pressure | 5e-22 | rs28570969 | 3 | GCST90132905 | no MR -> candidate analysis |
| Physical function (baseline) | 6e-22 | rs28391281 | 1 | GCST90565837 | no MR -> candidate analysis |
| Height | 2e-21 | rs2170169 | 7 | GCST90245845 | no MR -> candidate analysis |
| Autoimmune hypothyroidism | 4e-21 | rs12752271 | 1 | GCST90837324 | no MR -> candidate analysis |
| height (mean, inv-normal transformed) | 9e-21 | rs28611172 | 1 | GCST90479635 | no MR -> candidate analysis |
| Height (maximum, inv-normal transformed) | 3e-20 | rs28611172 | 1 | GCST90479634 | no MR -> candidate analysis |
| Body size (confirmatory factor analysis Factor 21) | 4e-18 | rs146988606 | 1 | GCST90309355 | no MR -> candidate analysis |
| height (minimum, inv-normal transformed) | 1e-17 | rs28611172 | 1 | GCST90479636 | no MR -> candidate analysis |
| …and 26 more traits (see JSON) |
Top diseases by Open Targets association (of 201 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hypothyroidism | 0.704 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.562 | — | common-variant locus | no MR -> candidate analysis |
| colorectal cancer | 0.562 | — | common-variant locus | no MR -> candidate analysis |
| thyroid gland disorder | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| heart failure | 0.503 | — | common-variant locus | no MR -> candidate analysis |
| myocardial infarction | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| coronary atherosclerosis | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| myxedema | 0.476 | — | common-variant locus | no MR -> candidate analysis |
| autoimmune thyroid disease | 0.466 | — | common-variant locus | no MR -> candidate analysis |
| migraine disorder | 0.432 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.434 | — | common-variant locus | no MR -> candidate analysis |
| Dent disease type 2 | 0.426 | — | established (curated) | no MR -> candidate analysis |
| coronary artery bypass | 0.394 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.384 | — | common-variant locus | no MR -> candidate analysis |
| myocardial ischemia | 0.378 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Type II inositol 1,4,5-trisphosphate 5-phosphatase) |
| gnomAD constraint | pLI=2.8e-23, LOEUF=0.905 — LoF-tolerant |
| GWAS Catalog | 84 unique SNPs / 168 rows |
| ClinVar | 236 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 201 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘INPP5B’ and resolved to ‘Type II inositol 1,4,5-trisphosphate 5-phosphatase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 236 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 38 traits by best p-value, aggregated from 63 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P32019 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000204084/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2636/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/INPP5B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/INPP5B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=INPP5B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/INPP5B — GWAS Catalog search API (live; release not exposed)