Protein Dossier — KDR (Vascular endothelial growth factor receptor 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.0564 |
0.0245 |
0.0213 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions |
0.368 |
0.173 |
0.0332 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
0.0117 |
0.00589 |
0.0469 |
Wald ratio |
1 |
cis |
NA |
| Cough on most days |
-0.0605 |
0.0313 |
0.0534 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K35 Acute appendicitis |
0.137 |
0.0731 |
0.0611 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
-0.108 |
0.0615 |
0.0778 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.0879 |
0.0502 |
0.0795 |
Wald ratio |
1 |
cis |
NA |
| Weight |
0.00884 |
0.00512 |
0.0846 |
Wald ratio |
1 |
cis |
NA |
| Hearing difficulty or problems: Yes |
0.0167 |
0.00984 |
0.0902 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Cataract |
0.0511 |
0.0302 |
0.091 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
-0.149 |
0.0886 |
0.0927 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
-0.0734 |
0.044 |
0.0954 |
Wald ratio |
1 |
cis |
NA |
| …and 55 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3651_50_5 |
VEGF sR2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
79 association rows across 37 traits (66 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating KDR levels (id: OID00677_OID21497) |
1e-1414 |
rs34231037 |
7 |
GCST90860021 |
no MR -> candidate analysis |
| Circulating KDR levels (id: OID00780_OID21497) |
7e-1370 |
rs34231037 |
7 |
GCST90860113 |
no MR -> candidate analysis |
| KDR protein levels |
2e-231 |
rs35389572 |
7 |
GCST90469672 |
no MR -> candidate analysis |
| Vascular endothelial growth factor receptor 2 levels (KDR.36 |
1e-70 |
rs34231037 |
2 |
GCST90243323 |
no MR -> candidate analysis |
| Serum levels of protein KDR |
5e-53 |
rs34231037 |
3 |
GCST90088480 |
no MR -> candidate analysis |
| Vascular endothelial growth factor receptor 2 levels |
2e-48 |
rs2305948 |
8 |
GCST90250164 |
no MR -> candidate analysis |
| Endometriosis |
2e-45 |
rs10517343 |
6 |
GCST90841381 |
no MR -> candidate analysis |
| Clinical endometriosis |
8e-31 |
rs10517343 |
2 |
GCST90841386 |
no MR -> candidate analysis |
| Endometriosis (MTAG) |
7e-27 |
rs1903068 |
2 |
GCST90570207 |
no MR -> candidate analysis |
| Dupuytren’s disease |
7e-23 |
rs73818546 |
2 |
GCST90301252 |
no MR -> candidate analysis |
| Self-reported endometriosis |
9e-22 |
rs10517343 |
1 |
GCST90841387 |
no MR -> candidate analysis |
| Blood protein levels |
6e-21 |
rs2305948 |
1 |
GCST006585 |
no MR -> candidate analysis |
| …and 25 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1602 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| neoplasm |
0.285 |
— |
established (curated) |
MR: beta=0.0663, p=0.149 (cis) |
| endometriosis |
0.88 |
— |
common-variant locus |
no MR -> candidate analysis |
| capillary infantile hemangioma |
0.547 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 3 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (TEL/KDR) |
| gnomAD constraint |
pLI=1, LOEUF=0.345 — LoF-INTOLERANT |
| GWAS Catalog |
53 unique SNPs / 106 rows |
| ClinVar |
277 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
7 clinical annotations across 3 drugs |
phenome — Top 30 of 1602 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘KDR’ and resolved to ‘TEL/KDR’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 277 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 37 traits by best p-value, aggregated from 79 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P35968 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000128052/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4630759/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/KDR — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/KDR — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=KDR%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=KDR — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/KDR — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:21:00 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none