Protein Dossier — KLK11 (Kallikrein-11)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Sodium in urine |
-0.0101 |
0.00364 |
0.00554 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: high cholesterol |
-0.0252 |
0.0103 |
0.014 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Diabetes related eye disease |
0.0979 |
0.043 |
0.0229 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
-0.124 |
0.0549 |
0.0233 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
-0.0729 |
0.0322 |
0.0235 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
-0.0918 |
0.0434 |
0.0344 |
Wald ratio |
1 |
cis |
NA |
| Urinary albumin-to-creatinine ratio |
-0.0309 |
0.015 |
0.0398 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gout |
-0.0671 |
0.0332 |
0.0434 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.0076 |
0.00384 |
0.0479 |
Wald ratio |
1 |
cis |
NA |
| Creatinine (enzymatic) in urine |
-0.00689 |
0.00354 |
0.0521 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
-0.00704 |
0.00376 |
0.0612 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
-0.0486 |
0.026 |
0.0616 |
Wald ratio |
1 |
cis |
NA |
| …and 89 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2831_29_1 |
Kallikrein 11 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
33 association rows across 22 traits (32 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| kallikrein-11 levels |
2e-1041 |
rs1048328 |
9 |
GCST90248156 |
no MR -> candidate analysis |
| Circulating KLK10 levels |
1e-777 |
rs2691208 |
1 |
GCST90860356 |
no MR -> candidate analysis |
| Kallikrein-11 (analyte X2831.29) levels |
1e-394 |
rs1048328 |
1 |
GCST90425490 |
no MR -> candidate analysis |
| Kallikrein-11 (analyte X7775.15) levels |
5e-379 |
rs1048328 |
1 |
GCST90427060 |
no MR -> candidate analysis |
| Blood protein levels |
1e-261 |
rs1048328 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Circulating KLK11 levels |
5e-186 |
rs62117662 |
1 |
GCST90860017 |
no MR -> candidate analysis |
| Kallikrein-11 levels (KLK11.2831.29.1) |
6e-186 |
rs1048328 |
1 |
GCST90241670 |
no MR -> candidate analysis |
| KLK11 protein levels |
2e-178 |
rs62117662 |
2 |
GCST90469697 |
no MR -> candidate analysis |
| Serum levels of protein KLK11 |
6e-153 |
rs1048328 |
1 |
GCST90089823 |
no MR -> candidate analysis |
| Protein S100-P levels |
7e-56 |
rs1048328 |
1 |
GCST90427997 |
no MR -> candidate analysis |
| Kallikrein-10 levels |
2e-33 |
rs3745539 |
1 |
GCST90179343 |
no MR -> candidate analysis |
| KLK7 protein levels |
9e-29 |
rs143406762 |
1 |
GCST90469706 |
no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 412 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| ichthyosis with erythrokeratoderma |
0.745 |
— |
established (curated) |
no MR -> candidate analysis |
| hereditary disease |
0.315 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Kallikrein-11) |
| gnomAD constraint |
pLI=0.22, LOEUF=0.725 — LoF-tolerant |
| GWAS Catalog |
172 unique SNPs / 454 rows |
| ClinVar |
78 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 412 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘KLK11’ and resolved to ‘Kallikrein-11’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 78 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 33 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UBX7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000167757/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3031/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/KLK11 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/KLK11 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=KLK11%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/KLK11 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:23:05 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none