Protein Dossier — KLK12 (Kallikrein-12)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Neo-extraversion |
0.286 |
0.119 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| Myocardial infarction |
0.043 |
0.0184 |
0.0193 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
-0.0677 |
0.0291 |
0.0202 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
-0.0767 |
0.0348 |
0.0276 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries |
-0.109 |
0.0511 |
0.0334 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
-0.0772 |
0.0365 |
0.0348 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M54 Dorsalgia |
0.0568 |
0.0284 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Iron |
0.0314 |
0.0158 |
0.0474 |
Wald ratio |
1 |
cis |
NA |
| Hearing difficulty or problems: Yes |
-0.0133 |
0.00677 |
0.0495 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.00589 |
0.00302 |
0.051 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N81 Female genital prolapse |
0.0589 |
0.0305 |
0.0533 |
Wald ratio |
1 |
cis |
NA |
| Packed cell volume |
0.0532 |
0.0276 |
0.054 |
Wald ratio |
1 |
cis |
NA |
| …and 96 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3199_54_2 |
kallikrein 12 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
50 association rows across 20 traits (48 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating KLK12 levels |
2e-7562 |
rs3745540 |
7 |
GCST90860580 |
no MR -> candidate analysis |
| Circulating KLK13 levels |
3e-1112 |
rs3760739 |
2 |
GCST90860002 |
no MR -> candidate analysis |
| Kallikrein-12 levels |
6e-212 |
rs3745540 |
7 |
GCST90161667 |
no MR -> candidate analysis |
| Kallikrein-13 levels |
3e-189 |
rs2569459 |
3 |
GCST90248158 |
no MR -> candidate analysis |
| KLK12 protein levels |
2e-182 |
rs77342236 |
9 |
GCST90469698 |
no MR -> candidate analysis |
| KLK10 protein levels |
6e-102 |
rs35996455 |
3 |
GCST90469696 |
no MR -> candidate analysis |
| Circulating KLK10 levels |
8e-101 |
rs3760744 |
1 |
GCST90860356 |
no MR -> candidate analysis |
| KLK14 protein levels |
2e-96 |
rs2569459 |
2 |
GCST90469700 |
no MR -> candidate analysis |
| Serum levels of protein KLK13 |
1e-79 |
rs2569459 |
2 |
GCST90086572 |
no MR -> candidate analysis |
| Blood protein levels |
4e-54 |
rs3760739 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Circulating KLK14 levels |
1e-44 |
rs8103083 |
1 |
GCST90860034 |
no MR -> candidate analysis |
| Kallikrein-12 levels (KLK12.3199.54.2) |
3e-34 |
rs3745540 |
1 |
GCST90241671 |
no MR -> candidate analysis |
| …and 8 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Kallikrein-12) |
| gnomAD constraint |
pLI=1.9e-09, LOEUF=1.63 — LoF-tolerant |
| GWAS Catalog |
190 unique SNPs / 466 rows |
| ClinVar |
76 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 84 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘KLK12’ and resolved to ‘Kallikrein-12’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 76 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 20 traits by best p-value, aggregated from 50 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UKR0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000186474/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4943/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/KLK12 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/KLK12 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=KLK12%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/KLK12 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:23:26 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none