Protein Dossier — KLK13 (Kallikrein-13)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Years of schooling |
0.0309 |
0.0103 |
0.0027 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.0149 |
0.00567 |
0.00838 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
-0.112 |
0.0438 |
0.0107 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
-0.0743 |
0.0312 |
0.0171 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
0.0959 |
0.0412 |
0.0199 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: H25 Senile cataract |
0.137 |
0.0647 |
0.0346 |
Wald ratio |
1 |
cis |
NA |
| Neo-agreeableness |
-0.356 |
0.176 |
0.0424 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
-0.149 |
0.0774 |
0.0542 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N81 Female genital prolapse |
0.0944 |
0.0494 |
0.056 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
0.0481 |
0.0263 |
0.0667 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
-0.184 |
0.103 |
0.0753 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pernicious anaemia |
0.178 |
0.101 |
0.0786 |
Wald ratio |
1 |
cis |
NA |
| …and 74 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3200_49_2 |
kallikrein 13 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
60 association rows across 23 traits (60 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating KLK12 levels |
6e-2130 |
rs62117666 |
5 |
GCST90860580 |
no MR -> candidate analysis |
| Circulating KLK13 levels |
3e-1112 |
rs3760739 |
4 |
GCST90860002 |
no MR -> candidate analysis |
| Kallikrein-13 levels |
3e-189 |
rs2569459 |
5 |
GCST90248158 |
no MR -> candidate analysis |
| KLK12 protein levels |
2e-182 |
rs77342236 |
11 |
GCST90469698 |
no MR -> candidate analysis |
| KLK13 protein levels |
2e-110 |
rs7253072 |
5 |
GCST90469699 |
no MR -> candidate analysis |
| Circulating KLK10 levels |
8e-101 |
rs3760744 |
1 |
GCST90860356 |
no MR -> candidate analysis |
| KLK14 protein levels |
2e-96 |
rs2569459 |
4 |
GCST90469700 |
no MR -> candidate analysis |
| Serum levels of protein KLK13 |
1e-79 |
rs2569459 |
3 |
GCST90086572 |
no MR -> candidate analysis |
| Blood protein levels |
4e-54 |
rs3760739 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Kallikrein-12 levels |
5e-50 |
rs8103941 |
3 |
GCST90101221 |
no MR -> candidate analysis |
| Kallikrein-13 (analyte X11152.46) levels |
2e-48 |
rs34089525 |
1 |
GCST90421334 |
no MR -> candidate analysis |
| Circulating KLK14 levels |
1e-44 |
rs8103083 |
1 |
GCST90860034 |
no MR -> candidate analysis |
| …and 11 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 309 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| actinic keratosis |
0.275 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Kallikrein-13) |
| gnomAD constraint |
pLI=2.2e-06, LOEUF=1.24 — LoF-tolerant |
| GWAS Catalog |
199 unique SNPs / 474 rows |
| ClinVar |
76 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 309 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘KLK13’ and resolved to ‘Kallikrein-13’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 76 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 23 traits by best p-value, aggregated from 60 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UKR3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000167759/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4863/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/KLK13 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/KLK13 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=KLK13%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/KLK13 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:23:47 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none