Protein Dossier — KLK14 (Kallikrein-14)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.432 |
0.144 |
0.0027 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0541 |
0.021 |
0.0102 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
-0.123 |
0.0479 |
0.0104 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: retinal detachment |
0.167 |
0.0675 |
0.0131 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
0.0112 |
0.00455 |
0.0142 |
Wald ratio |
1 |
cis |
NA |
| Small vessel disease |
-0.155 |
0.0663 |
0.0194 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus |
-0.102 |
0.0446 |
0.0226 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.103 |
0.0458 |
0.0246 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K40 Inguinal hernia |
-0.066 |
0.0298 |
0.0266 |
Wald ratio |
1 |
cis |
NA |
| Mean platelet volume |
-0.00435 |
0.00209 |
0.0372 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate |
0.104 |
0.0505 |
0.0396 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: joint disorder |
-0.158 |
0.0784 |
0.0446 |
Wald ratio |
1 |
cis |
NA |
| …and 96 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3681_87_3 |
kallikrein 14 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
71 association rows across 28 traits (69 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating KLK14 levels |
3e-856 |
rs2569491 |
5 |
GCST90860034 |
no MR -> candidate analysis |
| Circulating KLK13 levels |
1e-322 |
rs2569476 |
2 |
GCST90860002 |
no MR -> candidate analysis |
| KLK14 protein levels |
8e-231 |
rs34093024 |
12 |
GCST90469700 |
no MR -> candidate analysis |
| Kallikrein-14 levels (KLK14.8620.56.3) |
4e-119 |
rs2569491 |
2 |
GCST90241672 |
no MR -> candidate analysis |
| Serum levels of protein KLK14 |
9e-114 |
rs2569491 |
2 |
GCST90090240 |
no MR -> candidate analysis |
| KLK13 protein levels |
2e-110 |
rs7253072 |
4 |
GCST90469699 |
no MR -> candidate analysis |
| CD33 protein levels |
2e-106 |
rs867191 |
3 |
GCST90468625 |
no MR -> candidate analysis |
| Blood protein levels |
3e-86 |
rs2569491 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Sialic acid-binding Ig-like lectin 9 levels |
3e-73 |
rs2691273 |
5 |
GCST90101552 |
no MR -> candidate analysis |
| KLK12 protein levels |
1e-68 |
rs2569495 |
9 |
GCST90469698 |
no MR -> candidate analysis |
| SIGLEC9 protein levels |
3e-53 |
rs73051055 |
5 |
GCST90470637 |
no MR -> candidate analysis |
| Circulating SIGLEC7 levels |
2e-47 |
rs2569495 |
1 |
GCST90860368 |
no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 117 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcohol drinking |
0.191 |
— |
common-variant locus |
no MR -> candidate analysis |
| male infertility |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Kallikrein-14) |
| gnomAD constraint |
pLI=5.5e-07, LOEUF=1.23 — LoF-tolerant |
| GWAS Catalog |
175 unique SNPs / 448 rows |
| ClinVar |
56 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 117 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘KLK14’ and resolved to ‘Kallikrein-14’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 56 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 71 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9P0G3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000129437/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2641/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/KLK14 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/KLK14 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=KLK14%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/KLK14 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:24:17 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none