Protein Dossier — KLK7 (Kallikrein-7)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Age at menopause |
0.156 |
0.0569 |
0.00596 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hiatus hernia |
0.0896 |
0.0362 |
0.0132 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.0662 |
0.0271 |
0.0148 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Ankle |
0.111 |
0.0461 |
0.0162 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee |
0.0866 |
0.0372 |
0.0199 |
Wald ratio |
1 |
cis |
NA |
| Mean cell volume |
-0.219 |
0.0949 |
0.0209 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K40 Inguinal hernia |
0.0757 |
0.0341 |
0.0266 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
-0.0185 |
0.00853 |
0.0303 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0165 |
0.0078 |
0.0341 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.133 |
0.063 |
0.0342 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: iron deficiency anaemia |
0.151 |
0.0713 |
0.0347 |
Wald ratio |
1 |
cis |
NA |
| Lumbar spine bone mineral density |
0.0451 |
0.0217 |
0.0377 |
Wald ratio |
1 |
cis |
NA |
| …and 103 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3378_49_2 |
Kallikrein 7 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
47 association rows across 25 traits (44 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating KLK10 levels |
2e-587 |
rs1654530 |
2 |
GCST90860356 |
no MR -> candidate analysis |
| Circulating KLK8 levels |
1e-351 |
rs10418308 |
3 |
GCST90860020 |
no MR -> candidate analysis |
| KLK6/MOG protein level ratio |
6e-258 |
rs1654535 |
1 |
GCST90315255 |
no MR -> candidate analysis |
| KLK6/PTPRN2 protein level ratio |
5e-214 |
rs1654535 |
1 |
GCST90315256 |
no MR -> candidate analysis |
| KLK7 protein levels |
3e-168 |
rs148022792 |
2 |
GCST90469706 |
no MR -> candidate analysis |
| Kallikrein-7 levels |
5e-154 |
rs2659067 |
9 |
GCST90248163 |
no MR -> candidate analysis |
| Circulating KLK6 levels |
1e-85 |
rs57392237 |
1 |
GCST90859992 |
no MR -> candidate analysis |
| Kallikrein-8 levels |
5e-85 |
rs1122466 |
1 |
GCST90248164 |
no MR -> candidate analysis |
| Kallikrein-7 levels (KLK7.3378.49.2) |
1e-66 |
rs2739419 |
2 |
GCST90241679 |
no MR -> candidate analysis |
| Serum levels of protein KLK10 |
2e-57 |
rs57392237 |
1 |
GCST90089306 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein KLK7 levels |
8e-53 |
rs76662835 |
1 |
GCST90944381 |
no MR -> candidate analysis |
| kallikrein-11 levels |
2e-50 |
rs1122466 |
1 |
GCST90012012 |
no MR -> candidate analysis |
| …and 13 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 221 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| erythematosquamous dermatosis |
0.351 |
— |
common-variant locus |
no MR -> candidate analysis |
| seborrheic dermatitis |
0.316 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Kallikrein-7) |
| gnomAD constraint |
pLI=1.4e-05, LOEUF=1.21 — LoF-tolerant |
| GWAS Catalog |
167 unique SNPs / 422 rows |
| ClinVar |
74 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 221 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘KLK7’ and resolved to ‘Kallikrein-7’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 74 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 25 traits by best p-value, aggregated from 47 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P49862 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000169035/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2443/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/KLK7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/KLK7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=KLK7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/KLK7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:25:03 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none